LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Crizotinib | 1.11 | uM | LJP5 | 72 | hr | 1401 | 3386 | 4245 | 0.7956 | 0.7298 |
| SK-BR-3 | Crizotinib | 3.33 | uM | LJP5 | 72 | hr | 1401 | 2431 | 4245 | 0.5729 | 0.4101 |
| SK-BR-3 | Crizotinib | 10 | uM | LJP5 | 72 | hr | 1401 | 1239 | 4245 | 0.2904 | -0.0808 |
| SK-BR-3 | BMS345541 | 0.04 | uM | LJP6 | 72 | hr | 1401 | 4336 | 4168 | 1.0409 | 1.0521 |
| SK-BR-3 | BMS345541 | 0.12 | uM | LJP6 | 72 | hr | 1401 | 4153 | 4168 | 0.9958 | 0.9940 |
| SK-BR-3 | BMS345541 | 0.37 | uM | LJP6 | 72 | hr | 1401 | 3697 | 4168 | 0.8865 | 0.8518 |
| SK-BR-3 | BMS345541 | 1.11 | uM | LJP6 | 72 | hr | 1401 | 3166 | 4168 | 0.7593 | 0.6782 |
| SK-BR-3 | BMS345541 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 2205 | 4168 | 0.5282 | 0.3313 |
| SK-BR-3 | BMS345541 | 10 | uM | LJP6 | 72 | hr | 1401 | 766 | 4168 | 0.1838 | -0.3194 |
| SK-BR-3 | KIN001-043 | 0.04 | uM | LJP6 | 72 | hr | 1401 | 4174 | 4168 | 1.0021 | 1.0030 |
| SK-BR-3 | KIN001-043 | 0.12 | uM | LJP6 | 72 | hr | 1401 | 3926 | 4168 | 0.9418 | 0.9250 |
| SK-BR-3 | KIN001-043 | 0.37 | uM | LJP6 | 72 | hr | 1401 | 3311 | 4168 | 0.7944 | 0.7278 |
| SK-BR-3 | KIN001-043 | 1.11 | uM | LJP6 | 72 | hr | 1401 | 3301 | 4168 | 0.7926 | 0.7236 |
| SK-BR-3 | KIN001-043 | 3.33 | uM | LJP6 | 72 | hr | 1401 | 3438 | 4168 | 0.8261 | 0.7709 |
| SK-BR-3 | KIN001-043 | 10 | uM | LJP6 | 72 | hr | 1401 | 2362 | 4168 | 0.5671 | 0.3941 |
| SK-BR-3 | Saracatinib | 0.04 | uM | LJP6 | 72 | hr | 1401 | 4391 | 4168 | 1.0534 | 1.0672 |
| SK-BR-3 | Saracatinib | 0.12 | uM | LJP6 | 72 | hr | 1401 | 4520 | 4168 | 1.0838 | 1.1042 |
| SK-BR-3 | Saracatinib | 0.37 | uM | LJP6 | 72 | hr | 1401 | 4069 | 4168 | 0.9767 | 0.9705 |
| SK-BR-3 | Saracatinib | 1.11 | uM | LJP6 | 72 | hr | 1401 | 4181 | 4168 | 1.0029 | 1.0035 |
| SK-BR-3 | Saracatinib | 3.33 | uM | LJP6 | 72 | hr | 1401 | 3617 | 4168 | 0.8680 | 0.8278 |
| SK-BR-3 | Saracatinib | 10 | uM | LJP6 | 72 | hr | 1401 | 2100 | 4168 | 0.5045 | 0.2937 |
| SK-BR-3 | Sigma A6730 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 3699 | 4245 | 0.8708 | 0.8330 |
| SK-BR-3 | Sigma A6730 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 3636 | 4245 | 0.8565 | 0.8148 |
| SK-BR-3 | Sigma A6730 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 3559 | 4245 | 0.8377 | 0.7890 |
| SK-BR-3 | Sigma A6730 | 1.11 | uM | LJP5 | 72 | hr | 1401 | 3242 | 4245 | 0.7652 | 0.6920 |