LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Linifanib | 0.12 | uM | LJP6 | 72 | hr | 1209 | 3771 | 4012 | 0.9396 | 0.9290 |
| MCF7 | Linifanib | 0.37 | uM | LJP6 | 72 | hr | 1209 | 3857 | 4012 | 0.9609 | 0.9537 |
| MCF7 | Linifanib | 1.11 | uM | LJP6 | 72 | hr | 1209 | 3641 | 4012 | 0.9052 | 0.8843 |
| MCF7 | Linifanib | 3.33 | uM | LJP6 | 72 | hr | 1209 | 3423 | 4012 | 0.8506 | 0.8168 |
| MCF7 | Linifanib | 10 | uM | LJP6 | 72 | hr | 1209 | 1152 | 4012 | 0.2863 | -0.0318 |
| MCF7 | PIK-93 | 0.04 | uM | LJP5 | 72 | hr | 1209 | 4130 | 4203 | 0.9830 | 0.9812 |
| MCF7 | PIK-93 | 0.12 | uM | LJP5 | 72 | hr | 1209 | 3784 | 4203 | 0.8997 | 0.8845 |
| MCF7 | PIK-93 | 0.37 | uM | LJP5 | 72 | hr | 1209 | 3322 | 4203 | 0.7911 | 0.7557 |
| MCF7 | PIK-93 | 1.11 | uM | LJP5 | 72 | hr | 1209 | 2696 | 4203 | 0.6431 | 0.5636 |
| MCF7 | PIK-93 | 3.33 | uM | LJP5 | 72 | hr | 1209 | 1983 | 4203 | 0.4733 | 0.3182 |
| MCF7 | PIK-93 | 10 | uM | LJP5 | 72 | hr | 1209 | 1189 | 4203 | 0.2834 | -0.0094 |
| MCF7 | Dactolisib | 0.04 | uM | LJP5 | 72 | hr | 1209 | 1186 | 4203 | 0.2829 | -0.0105 |
| MCF7 | Dactolisib | 0.12 | uM | LJP5 | 72 | hr | 1209 | 1071 | 4203 | 0.2559 | -0.0649 |
| MCF7 | Dactolisib | 0.37 | uM | LJP5 | 72 | hr | 1209 | 962 | 4203 | 0.2296 | -0.1195 |
| MCF7 | Dactolisib | 1.11 | uM | LJP5 | 72 | hr | 1209 | 980 | 4203 | 0.2337 | -0.1106 |
| MCF7 | Dactolisib | 3.33 | uM | LJP5 | 72 | hr | 1209 | 1140 | 4203 | 0.2718 | -0.0323 |
| MCF7 | Dactolisib | 10 | uM | LJP5 | 72 | hr | 1209 | 1240 | 4203 | 0.2962 | 0.0146 |
| MCF7 | Alpelisib | 0.04 | uM | LJP5 | 72 | hr | 1209 | 3283 | 4203 | 0.7827 | 0.7454 |
| MCF7 | Alpelisib | 0.12 | uM | LJP5 | 72 | hr | 1209 | 2769 | 4203 | 0.6595 | 0.5859 |
| MCF7 | Alpelisib | 0.37 | uM | LJP5 | 72 | hr | 1209 | 2069 | 4203 | 0.4930 | 0.3487 |
| MCF7 | Alpelisib | 1.11 | uM | LJP5 | 72 | hr | 1209 | 1779 | 4203 | 0.4239 | 0.2399 |
| MCF7 | Alpelisib | 3.33 | uM | LJP5 | 72 | hr | 1209 | 1459 | 4203 | 0.3481 | 0.1108 |
| MCF7 | Alpelisib | 10 | uM | LJP5 | 72 | hr | 1209 | 1130 | 4203 | 0.2698 | -0.0366 |
| MCF7 | GDC-0980 | 0.04 | uM | LJP5 | 72 | hr | 1209 | 1300 | 4203 | 0.3098 | 0.0411 |
| MCF7 | GDC-0980 | 0.12 | uM | LJP5 | 72 | hr | 1209 | 1002 | 4203 | 0.2390 | -0.1001 |