LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1235 | 108 | 4405 | 0.0247 | -0.7348 |
| MCF 10A | CGP60474 | 0.37 | uM | LJP5 | 72 | hr | 962 | 263 | 10512 | 0.0251 | -0.3130 |
| MCF 10A | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 962 | 273 | 10692 | 0.0256 | -0.3071 |
| MCF 10A | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 962 | 277 | 10692 | 0.0260 | -0.3019 |
| SK-BR-3 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1401 | 109 | 4168 | 0.0261 | -0.8036 |
| MCF 10A | CGP60474 | 10 | uM | LJP6 | 72 | hr | 962 | 279 | 10692 | 0.0261 | -0.2996 |
| MCF 10A | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 962 | 294 | 10692 | 0.0276 | -0.2895 |
| Hs 578T | AZD8055 | 10 | uM | LJP6 | 72 | hr | 658 | 103 | 3761 | 0.0276 | -0.5223 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 962 | 292 | 10512 | 0.0278 | -0.2931 |
| MDA-MB-231 | PHA-665752 | 10 | uM | LJP5 | 72 | hr | 1235 | 131 | 4660 | 0.0282 | -0.6902 |
| MCF 10A | A443654 | 3.33 | uM | LJP6 | 72 | hr | 962 | 316 | 10692 | 0.0296 | -0.2756 |
| MCF 10A | Alvocidib | 0.12 | uM | LJP6 | 72 | hr | 962 | 320 | 10692 | 0.0299 | -0.2716 |
| MCF 10A | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 962 | 319 | 10692 | 0.0299 | -0.2726 |
| MCF 10A | SNS-032 | 10 | uM | LJP6 | 72 | hr | 962 | 324 | 10692 | 0.0303 | -0.2777 |
| MCF 10A | CGP60474 | 10 | uM | LJP5 | 72 | hr | 962 | 326 | 10512 | 0.0310 | -0.2699 |
| MCF 10A | AZD 5438 | 10 | uM | LJP6 | 72 | hr | 962 | 333 | 10692 | 0.0312 | -0.2640 |
| Hs 578T | SB590885 | 10 | uM | LJP5 | 72 | hr | 658 | 125 | 3933 | 0.0320 | -0.4740 |
| BT-20 | AZD8055 | 10 | uM | LJP6 | 72 | hr | 1097 | 119 | 3673 | 0.0326 | -0.7198 |
| MCF 10A | PHA-793887 | 10 | uM | LJP6 | 72 | hr | 962 | 359 | 10692 | 0.0336 | -0.2493 |
| MCF 10A | PF562271 | 10 | uM | LJP6 | 72 | hr | 962 | 369 | 10692 | 0.0345 | -0.2412 |
| MCF 10A | Celastrol | 3.33 | uM | LJP6 | 72 | hr | 962 | 374 | 10692 | 0.0350 | -0.2380 |
| MCF 10A | Radicicol | 10 | uM | LJP6 | 72 | hr | 962 | 381 | 10692 | 0.0357 | -0.2339 |
| MCF 10A | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 962 | 380 | 10512 | 0.0361 | -0.2392 |
| MCF 10A | Geldanamycin | 10 | uM | LJP6 | 72 | hr | 962 | 393 | 10692 | 0.0367 | -0.2277 |
| MCF 10A | CGP60474 | 0.12 | uM | LJP5 | 72 | hr | 962 | 387 | 10512 | 0.0368 | -0.2331 |