LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | CP466722 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 4613 | 4245 | 1.0928 | 1.1181 |
| SK-BR-3 | Imatinib | 0.12 | uM | LJP6 | 72 | hr | 1401 | 4559 | 4168 | 1.0934 | 1.1167 |
| SK-BR-3 | Linifanib | 0.04 | uM | LJP6 | 72 | hr | 1401 | 4563 | 4168 | 1.0943 | 1.1173 |
| MCF7 | Y39983 | 0.04 | uM | LJP6 | 72 | hr | 1209 | 4386 | 4012 | 1.0946 | 1.1082 |
| BT-20 | PD173074 | 3.33 | uM | LJP6 | 72 | hr | 1097 | 4036 | 3673 | 1.0993 | 1.1117 |
| SK-BR-3 | Imatinib | 1.11 | uM | LJP6 | 72 | hr | 1401 | 4581 | 4168 | 1.0994 | 1.1246 |
| SK-BR-3 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4661 | 4245 | 1.0997 | 1.1246 |
| Hs 578T | Sorafenib | 0.12 | uM | LJP6 | 72 | hr | 658 | 4138 | 3761 | 1.1003 | 1.0774 |
| MDA-MB-231 | Nintedanib | 0.04 | uM | LJP6 | 72 | hr | 1235 | 4845 | 4405 | 1.1005 | 1.1078 |
| MCF 10A | Enzastaurin | 3.33 | uM | LJP5 | 72 | hr | 962 | 11572 | 10512 | 1.1008 | 1.0564 |
| BT-20 | Withaferin A | 0.12 | uM | LJP5 | 72 | hr | 1097 | 4236 | 3846 | 1.1019 | 1.1104 |
| SK-BR-3 | SB590885 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 4685 | 4245 | 1.1047 | 1.1302 |
| BT-20 | Enzastaurin | 3.33 | uM | LJP5 | 72 | hr | 1097 | 4264 | 3846 | 1.1084 | 1.1156 |
| SK-BR-3 | Selumetinib | 0.04 | uM | LJP6 | 72 | hr | 1401 | 4622 | 4168 | 1.1095 | 1.1372 |
| MDA-MB-231 | Linifanib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 4890 | 4405 | 1.1105 | 1.1181 |
| MDA-MB-231 | Enzastaurin | 10 | uM | LJP5 | 72 | hr | 1235 | 5177 | 4660 | 1.1109 | 1.1130 |
| SK-BR-3 | Nilotinib | 0.12 | uM | LJP5 | 72 | hr | 1401 | 4727 | 4245 | 1.1110 | 1.1335 |
| Hs 578T | SB590885 | 0.04 | uM | LJP5 | 72 | hr | 658 | 4370 | 3933 | 1.1111 | 1.0833 |
| SK-BR-3 | XL147 | 0.37 | uM | LJP5 | 72 | hr | 1401 | 4686 | 4245 | 1.1119 | 1.1421 |
| SK-BR-3 | SB590885 | 1.11 | uM | LJP5 | 72 | hr | 1401 | 4714 | 4245 | 1.1121 | 1.1397 |
| SK-BR-3 | Nilotinib | 0.04 | uM | LJP5 | 72 | hr | 1401 | 4725 | 4245 | 1.1140 | 1.1414 |
| BT-20 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1097 | 4280 | 3846 | 1.1141 | 1.1232 |
| SK-BR-3 | Nilotinib | 3.33 | uM | LJP5 | 72 | hr | 1401 | 4741 | 4245 | 1.1176 | 1.1453 |
| BT-20 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1097 | 4302 | 3846 | 1.1181 | 1.1267 |
| MDA-MB-231 | PD173074 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 4916 | 4405 | 1.1188 | 1.1268 |