LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Alvocidib | 0.12 | uM | LJP6 | 72 | hr | 962 | 320 | 10692 | 0.0299 | -0.2716 |
| MCF7 | PF562271 | 10 | uM | LJP6 | 72 | hr | 1209 | 701 | 4012 | 0.1746 | -0.2714 |
| MCF7 | XMD16-144 | 10 | uM | LJP5 | 72 | hr | 1209 | 685 | 4203 | 0.1634 | -0.2713 |
| MCF7 | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 1209 | 702 | 4012 | 0.1752 | -0.2704 |
| MCF7 | WZ3105 | 10 | uM | LJP5 | 72 | hr | 1209 | 687 | 4203 | 0.1638 | -0.2703 |
| MCF7 | Geldanamycin | 10 | uM | LJP6 | 72 | hr | 1209 | 706 | 4012 | 0.1755 | -0.2703 |
| SK-BR-3 | Omipalisib | 10 | uM | LJP6 | 72 | hr | 1401 | 855 | 4168 | 0.2050 | -0.2702 |
| BT-20 | Buparlisib | 10 | uM | LJP5 | 72 | hr | 1097 | 621 | 3846 | 0.1617 | -0.2699 |
| MCF 10A | CGP60474 | 10 | uM | LJP5 | 72 | hr | 962 | 326 | 10512 | 0.0310 | -0.2699 |
| BT-20 | Alvocidib | 3.33 | uM | LJP6 | 72 | hr | 1097 | 635 | 3673 | 0.1731 | -0.2694 |
| SK-BR-3 | AZD7762 | 10 | uM | LJP6 | 72 | hr | 1401 | 856 | 4168 | 0.2056 | -0.2694 |
| MCF7 | Mitoxantrone | 1.11 | uM | LJP5 | 72 | hr | 1209 | 691 | 4203 | 0.1645 | -0.2684 |
| BT-20 | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 1097 | 627 | 3846 | 0.1628 | -0.2677 |
| MCF7 | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1209 | 707 | 4012 | 0.1766 | -0.2676 |
| MDA-MB-231 | PD0325901 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 735 | 4405 | 0.1652 | -0.2656 |
| MCF7 | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 1209 | 712 | 4012 | 0.1776 | -0.2642 |
| Hs 578T | AT-7519 | 10 | uM | LJP6 | 72 | hr | 658 | 304 | 3761 | 0.0811 | -0.2642 |
| MCF 10A | AZD 5438 | 10 | uM | LJP6 | 72 | hr | 962 | 333 | 10692 | 0.0312 | -0.2640 |
| BT-20 | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 1097 | 643 | 3673 | 0.1752 | -0.2638 |
| SK-BR-3 | NVP-TAE684 | 10 | uM | LJP6 | 72 | hr | 1401 | 870 | 4168 | 0.2092 | -0.2623 |
| Hs 578T | A443654 | 1.11 | uM | LJP6 | 72 | hr | 658 | 308 | 3761 | 0.0819 | -0.2618 |
| MDA-MB-231 | Luminespib | 10 | uM | LJP5 | 72 | hr | 1235 | 696 | 4660 | 0.1492 | -0.2605 |
| SK-BR-3 | WZ3105 | 0.12 | uM | LJP5 | 72 | hr | 1401 | 871 | 4245 | 0.2055 | -0.2592 |
| MCF7 | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 1209 | 720 | 4012 | 0.1798 | -0.2592 |
| MDA-MB-231 | XMD16-144 | 10 | uM | LJP5 | 72 | hr | 1235 | 699 | 4660 | 0.1498 | -0.2589 |