LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Fedratinib | 1.11 | uM | LJP5 | 72 | hr | 1209 | 2137 | 4203 | 0.5086 | 0.3720 |
| MCF7 | Fedratinib | 3.33 | uM | LJP5 | 72 | hr | 1209 | 1391 | 4203 | 0.3314 | 0.0808 |
| MCF7 | Fedratinib | 10 | uM | LJP5 | 72 | hr | 1209 | 626 | 4203 | 0.1491 | -0.3074 |
| MCF7 | Trametinib | 0.04 | uM | LJP5 | 72 | hr | 1209 | 2188 | 4203 | 0.5203 | 0.3892 |
| MCF7 | Trametinib | 0.12 | uM | LJP5 | 72 | hr | 1209 | 2030 | 4203 | 0.4836 | 0.3343 |
| MCF7 | Trametinib | 0.37 | uM | LJP5 | 72 | hr | 1209 | 2084 | 4203 | 0.4969 | 0.3541 |
| MCF7 | Trametinib | 1.11 | uM | LJP5 | 72 | hr | 1209 | 2203 | 4203 | 0.5255 | 0.3977 |
| MCF7 | Trametinib | 3.33 | uM | LJP5 | 72 | hr | 1209 | 2307 | 4203 | 0.5498 | 0.4332 |
| MCF7 | Trametinib | 10 | uM | LJP5 | 72 | hr | 1209 | 2277 | 4203 | 0.5423 | 0.4214 |
| MCF7 | Omipalisib | 0.04 | uM | LJP6 | 72 | hr | 1209 | 1105 | 4012 | 0.2753 | -0.0519 |
| MCF7 | Omipalisib | 0.12 | uM | LJP6 | 72 | hr | 1209 | 1054 | 4012 | 0.2631 | -0.0763 |
| MCF7 | Omipalisib | 0.37 | uM | LJP6 | 72 | hr | 1209 | 1105 | 4012 | 0.2754 | -0.0517 |
| MCF7 | Omipalisib | 1.11 | uM | LJP6 | 72 | hr | 1209 | 1102 | 4012 | 0.2752 | -0.0522 |
| MCF7 | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 1209 | 1073 | 4012 | 0.2676 | -0.0671 |
| MCF7 | Omipalisib | 10 | uM | LJP6 | 72 | hr | 1209 | 903 | 4012 | 0.2257 | -0.1551 |
| MCF7 | Buparlisib | 0.04 | uM | LJP5 | 72 | hr | 1209 | 2423 | 4203 | 0.5774 | 0.4727 |
| MCF7 | Buparlisib | 0.12 | uM | LJP5 | 72 | hr | 1209 | 1881 | 4203 | 0.4487 | 0.2797 |
| MCF7 | Buparlisib | 0.37 | uM | LJP5 | 72 | hr | 1209 | 1418 | 4203 | 0.3381 | 0.0929 |
| MCF7 | Buparlisib | 1.11 | uM | LJP5 | 72 | hr | 1209 | 977 | 4203 | 0.2331 | -0.1118 |
| MCF7 | Buparlisib | 3.33 | uM | LJP5 | 72 | hr | 1209 | 838 | 4203 | 0.1998 | -0.1851 |
| MCF7 | Buparlisib | 10 | uM | LJP5 | 72 | hr | 1209 | 854 | 4203 | 0.2032 | -0.1769 |
| MCF7 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1209 | 4436 | 4203 | 1.0594 | 1.0668 |
| MCF7 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1209 | 4346 | 4203 | 1.0343 | 1.0377 |
| MCF7 | XL147 | 0.37 | uM | LJP5 | 72 | hr | 1209 | 4269 | 4203 | 1.0166 | 1.0189 |
| MCF7 | XL147 | 1.11 | uM | LJP5 | 72 | hr | 1209 | 4323 | 4203 | 1.0297 | 1.0336 |