LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | ZSTK474 | 1.11 | uM | LJP6 | 72 | hr | 1209 | 1160 | 4012 | 0.2889 | -0.0252 |
| MCF7 | ZSTK474 | 3.33 | uM | LJP6 | 72 | hr | 1209 | 1057 | 4012 | 0.2635 | -0.0756 |
| MCF7 | ZSTK474 | 10 | uM | LJP6 | 72 | hr | 1209 | 925 | 4012 | 0.2310 | -0.1435 |
| MCF7 | BX-912 | 0.04 | uM | LJP5 | 72 | hr | 1209 | 3738 | 4203 | 0.8904 | 0.8752 |
| MCF7 | BX-912 | 0.12 | uM | LJP5 | 72 | hr | 1209 | 3549 | 4203 | 0.8453 | 0.8211 |
| MCF7 | BX-912 | 0.37 | uM | LJP5 | 72 | hr | 1209 | 2683 | 4203 | 0.6391 | 0.5586 |
| MCF7 | BX-912 | 1.11 | uM | LJP5 | 72 | hr | 1209 | 2139 | 4203 | 0.5093 | 0.3733 |
| MCF7 | BX-912 | 3.33 | uM | LJP5 | 72 | hr | 1209 | 1766 | 4203 | 0.4209 | 0.2346 |
| MCF7 | BX-912 | 10 | uM | LJP5 | 72 | hr | 1209 | 1186 | 4203 | 0.2827 | -0.0110 |
| MCF7 | Selumetinib | 0.04 | uM | LJP6 | 72 | hr | 1209 | 3122 | 4012 | 0.7787 | 0.7308 |
| MCF7 | Selumetinib | 0.12 | uM | LJP6 | 72 | hr | 1209 | 2770 | 4012 | 0.6907 | 0.6145 |
| MCF7 | Selumetinib | 0.37 | uM | LJP6 | 72 | hr | 1209 | 2499 | 4012 | 0.6214 | 0.5164 |
| MCF7 | Selumetinib | 1.11 | uM | LJP6 | 72 | hr | 1209 | 2517 | 4012 | 0.6272 | 0.5266 |
| MCF7 | Selumetinib | 3.33 | uM | LJP6 | 72 | hr | 1209 | 2748 | 4012 | 0.6851 | 0.6070 |
| MCF7 | Selumetinib | 10 | uM | LJP6 | 72 | hr | 1209 | 2522 | 4012 | 0.6297 | 0.5307 |
| MCF7 | MK2206 | 0.04 | uM | LJP6 | 72 | hr | 1209 | 2425 | 4012 | 0.6048 | 0.4946 |
| MCF7 | MK2206 | 0.12 | uM | LJP6 | 72 | hr | 1209 | 2265 | 4012 | 0.5652 | 0.4375 |
| MCF7 | MK2206 | 0.37 | uM | LJP6 | 72 | hr | 1209 | 2043 | 4012 | 0.5097 | 0.3543 |
| MCF7 | MK2206 | 1.11 | uM | LJP6 | 72 | hr | 1209 | 1819 | 4012 | 0.4540 | 0.2666 |
| MCF7 | MK2206 | 3.33 | uM | LJP6 | 72 | hr | 1209 | 1618 | 4012 | 0.4034 | 0.1829 |
| MCF7 | MK2206 | 10 | uM | LJP6 | 72 | hr | 1209 | 1071 | 4012 | 0.2669 | -0.0688 |
| MCF7 | AZD-6482 | 0.04 | uM | LJP5 | 72 | hr | 1209 | 4152 | 4203 | 0.9873 | 0.9851 |
| MCF7 | AZD-6482 | 0.12 | uM | LJP5 | 72 | hr | 1209 | 4042 | 4203 | 0.9628 | 0.9588 |
| MCF7 | AZD-6482 | 0.37 | uM | LJP5 | 72 | hr | 1209 | 4050 | 4203 | 0.9637 | 0.9592 |
| MCF7 | AZD-6482 | 1.11 | uM | LJP5 | 72 | hr | 1209 | 3734 | 4203 | 0.8897 | 0.8745 |