LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Geldanamycin | 1.11 | uM | LJP5 | 72 | hr | 1694 | 1452 | 11103 | 0.1308 | -0.0555 |
| Hs 578T | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 765 | 405 | 3101 | 0.1308 | -0.2708 |
| Hs 578T | WZ3105 | 3.33 | uM | LJP5 | 72 | hr | 765 | 412 | 3148 | 0.1309 | -0.2617 |
| Hs 578T | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 765 | 412 | 3148 | 0.1310 | -0.2619 |
| MCF 10A | Radicicol | 3.33 | uM | LJP6 | 72 | hr | 1694 | 1471 | 11217 | 0.1312 | -0.0507 |
| Hs 578T | BX-912 | 10 | uM | LJP5 | 72 | hr | 765 | 415 | 3148 | 0.1319 | -0.2589 |
| MCF 10A | Mitoxantrone | 0.37 | uM | LJP6 | 72 | hr | 1694 | 1479 | 11217 | 0.1319 | -0.0487 |
| MCF7 | Foretinib | 10 | uM | LJP5 | 72 | hr | 1389 | 782 | 5905 | 0.1322 | -0.2418 |
| MDA-MB-231 | AZD 5438 | 10 | uM | LJP6 | 72 | hr | 1311 | 652 | 4935 | 0.1322 | -0.3061 |
| Hs 578T | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 765 | 410 | 3101 | 0.1323 | -0.2656 |
| MCF 10A | GSK1059615 | 10 | uM | LJP5 | 72 | hr | 1694 | 1469 | 11103 | 0.1323 | -0.0513 |
| MCF7 | Pelitinib | 10 | uM | LJP5 | 72 | hr | 1389 | 782 | 5905 | 0.1325 | -0.2405 |
| Hs 578T | Geldanamycin | 10 | uM | LJP6 | 72 | hr | 765 | 410 | 3101 | 0.1327 | -0.2725 |
| Hs 578T | QL-XII-47 | 10 | uM | LJP6 | 72 | hr | 765 | 412 | 3101 | 0.1329 | -0.2644 |
| Hs 578T | JW-7-24-1 | 10 | uM | LJP6 | 72 | hr | 765 | 414 | 3101 | 0.1335 | -0.2622 |
| MCF 10A | GSK1059615 | 10 | uM | LJP6 | 72 | hr | 1694 | 1500 | 11217 | 0.1337 | -0.0462 |
| MCF 10A | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 1694 | 1499 | 11217 | 0.1337 | -0.0455 |
| SK-BR-3 | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 2543 | 768 | 5752 | 0.1337 | -0.6393 |
| MCF7 | CGP60474 | 0.04 | uM | LJP6 | 72 | hr | 1389 | 727 | 5445 | 0.1339 | -0.2802 |
| Hs 578T | Dasatinib | 3.33 | uM | LJP6 | 72 | hr | 765 | 416 | 3101 | 0.1344 | -0.2603 |
| Hs 578T | TWS119 | 10 | uM | LJP5 | 72 | hr | 765 | 424 | 3148 | 0.1349 | -0.2511 |
| Hs 578T | SNS-032 | 0.12 | uM | LJP6 | 72 | hr | 765 | 419 | 3101 | 0.1351 | -0.2579 |
| SK-BR-3 | AZD 5438 | 10 | uM | LJP6 | 72 | hr | 2543 | 733 | 5418 | 0.1352 | -0.6804 |
| BT-20 | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 1334 | 531 | 3925 | 0.1353 | -0.4470 |
| Hs 578T | CGP60474 | 10 | uM | LJP5 | 72 | hr | 765 | 428 | 3148 | 0.1360 | -0.2478 |