LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 1334 | 423 | 3925 | 0.1078 | -0.5225 |
| Hs 578T | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 765 | 174 | 3101 | 0.0564 | -0.5216 |
| Hs 578T | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 765 | 172 | 3148 | 0.0546 | -0.5188 |
| SK-BR-3 | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 2543 | 1155 | 5418 | 0.2129 | -0.5157 |
| SK-BR-3 | Alvocidib | 0.12 | uM | LJP6 | 72 | hr | 2543 | 1157 | 5418 | 0.2130 | -0.5153 |
| MCF 10A | Withaferin A | 10 | uM | LJP6 | 72 | hr | 1694 | 241 | 11217 | 0.0215 | -0.5109 |
| MCF7 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1389 | 345 | 5445 | 0.0630 | -0.5105 |
| BT-20 | GSK1059615 | 3.33 | uM | LJP5 | 72 | hr | 1334 | 428 | 4033 | 0.1061 | -0.5104 |
| MCF7 | AT-7519 | 10 | uM | LJP6 | 72 | hr | 1389 | 344 | 5445 | 0.0635 | -0.5080 |
| SK-BR-3 | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 2543 | 1181 | 5418 | 0.2178 | -0.5056 |
| SK-BR-3 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 2543 | 1182 | 5418 | 0.2179 | -0.5053 |
| SK-BR-3 | Torin2 | 10 | uM | LJP5 | 72 | hr | 2543 | 1112 | 5752 | 0.1933 | -0.5048 |
| MCF 10A | AT-7519 | 10 | uM | LJP6 | 72 | hr | 1694 | 253 | 11217 | 0.0226 | -0.5030 |
| BT-20 | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 1334 | 439 | 4033 | 0.1089 | -0.5020 |
| SK-BR-3 | BI-2536 | 10 | uM | LJP6 | 72 | hr | 2543 | 1198 | 5418 | 0.2210 | -0.4991 |
| SK-BR-3 | A443654 | 1.11 | uM | LJP6 | 72 | hr | 2543 | 1204 | 5418 | 0.2225 | -0.4962 |
| Hs 578T | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 765 | 189 | 3148 | 0.0601 | -0.4956 |
| SK-BR-3 | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 2543 | 1140 | 5752 | 0.1982 | -0.4943 |
| SK-BR-3 | TWS119 | 10 | uM | LJP5 | 72 | hr | 2543 | 1147 | 5752 | 0.1994 | -0.4923 |
| MCF7 | CGP60474 | 10 | uM | LJP5 | 72 | hr | 1389 | 343 | 5905 | 0.0581 | -0.4884 |
| SK-BR-3 | AZD7762 | 10 | uM | LJP6 | 72 | hr | 2543 | 1226 | 5418 | 0.2264 | -0.4880 |
| MCF 10A | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1694 | 279 | 11217 | 0.0249 | -0.4874 |
| BT-20 | Buparlisib | 10 | uM | LJP5 | 72 | hr | 1334 | 463 | 4033 | 0.1148 | -0.4855 |
| SK-BR-3 | GSK1059615 | 3.33 | uM | LJP5 | 72 | hr | 2543 | 1167 | 5752 | 0.2030 | -0.4844 |
| BT-20 | Omipalisib | 10 | uM | LJP6 | 72 | hr | 1334 | 479 | 3925 | 0.1221 | -0.4825 |