LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Dovitinib | 10 | uM | LJP5 | 72 | hr | 1389 | 2573 | 5905 | 0.4351 | 0.3413 |
| MCF7 | HG-5-113-01 | 0.37 | uM | LJP5 | 72 | hr | 1389 | 3820 | 5905 | 0.6458 | 0.6201 |
| MCF7 | BX-912 | 0.04 | uM | LJP5 | 72 | hr | 1389 | 4745 | 5905 | 0.8033 | 0.8007 |
| MCF7 | BX-912 | 0.12 | uM | LJP5 | 72 | hr | 1389 | 5484 | 5905 | 0.9298 | 0.9315 |
| MCF7 | BX-912 | 0.37 | uM | LJP5 | 72 | hr | 1389 | 5266 | 5905 | 0.8911 | 0.8918 |
| MCF7 | BX-912 | 1.11 | uM | LJP5 | 72 | hr | 1389 | 3569 | 5905 | 0.6040 | 0.5703 |
| MCF7 | BX-912 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 2637 | 5905 | 0.4465 | 0.3590 |
| MCF7 | BX-912 | 10 | uM | LJP5 | 72 | hr | 1389 | 1535 | 5905 | 0.2600 | 0.0489 |
| MCF7 | CGP60474 | 0.12 | uM | LJP5 | 72 | hr | 1389 | 1029 | 5905 | 0.1735 | -0.1408 |
| MCF7 | HG-5-113-01 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 1646 | 5905 | 0.2786 | 0.0840 |
| MCF7 | Linsitinib | 0.04 | uM | LJP5 | 72 | hr | 1389 | 4291 | 5905 | 0.7258 | 0.7143 |
| MCF7 | CGP60474 | 0.37 | uM | LJP5 | 72 | hr | 1389 | 465 | 5905 | 0.0787 | -0.4081 |
| MCF7 | Linsitinib | 0.37 | uM | LJP5 | 72 | hr | 1389 | 4606 | 5905 | 0.7791 | 0.7735 |
| MCF7 | HG-5-113-01 | 10 | uM | LJP5 | 72 | hr | 1389 | 990 | 5905 | 0.1674 | -0.1512 |
| MCF7 | Ruxolitinib | 0.12 | uM | LJP5 | 72 | hr | 1389 | 5443 | 5905 | 0.9227 | 0.9245 |
| MCF7 | CGP60474 | 1.11 | uM | LJP5 | 72 | hr | 1389 | 397 | 5905 | 0.0672 | -0.4513 |
| MCF7 | Ruxolitinib | 1.11 | uM | LJP5 | 72 | hr | 1389 | 6306 | 5905 | 1.0669 | 1.0620 |
| MCF7 | Momelotinib | 0.04 | uM | LJP5 | 72 | hr | 1389 | 5533 | 5905 | 0.9370 | 0.9386 |
| MCF7 | Momelotinib | 0.12 | uM | LJP5 | 72 | hr | 1389 | 5704 | 5905 | 0.9670 | 0.9682 |
| MCF7 | CGP60474 | 3.33 | uM | LJP5 | 72 | hr | 1389 | 359 | 5905 | 0.0608 | -0.4776 |
| MCF7 | AZD-6482 | 0.04 | uM | LJP5 | 72 | hr | 1389 | 6084 | 5905 | 1.0297 | 1.0278 |
| MCF7 | AZD-6482 | 0.12 | uM | LJP5 | 72 | hr | 1389 | 6014 | 5905 | 1.0180 | 1.0168 |
| MCF7 | AZD-6482 | 0.37 | uM | LJP5 | 72 | hr | 1389 | 6318 | 5905 | 1.0688 | 1.0636 |
| MCF7 | Trametinib | 1.11 | uM | LJP5 | 72 | hr | 1389 | 2616 | 5905 | 0.4428 | 0.3535 |
| MCF7 | Trametinib | 0.37 | uM | LJP5 | 72 | hr | 1389 | 2689 | 5905 | 0.4554 | 0.3720 |