LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 513 | 374 | 10362 | 0.0362 | -0.0703 |
| MCF7 | AZD 5438 | 10 | uM | LJP6 | 72 | hr | 1235 | 381 | 4056 | 0.0939 | -0.4975 |
| MCF7 | CGP60474 | 10 | uM | LJP6 | 72 | hr | 1235 | 383 | 4056 | 0.0945 | -0.4947 |
| MCF 10A | TWS119 | 10 | uM | LJP5 | 72 | hr | 513 | 385 | 10362 | 0.0372 | -0.0639 |
| MCF 10A | Buparlisib | 3.33 | uM | LJP5 | 72 | hr | 513 | 386 | 10362 | 0.0372 | -0.0664 |
| MCF 10A | Mitoxantrone | 1.11 | uM | LJP5 | 72 | hr | 513 | 387 | 10362 | 0.0373 | -0.0633 |
| MCF 10A | Geldanamycin | 3.33 | uM | LJP5 | 72 | hr | 513 | 389 | 10362 | 0.0376 | -0.0630 |
| MCF 10A | Geldanamycin | 3.33 | uM | LJP6 | 72 | hr | 513 | 393 | 10473 | 0.0375 | -0.0601 |
| MCF 10A | Omipalisib | 10 | uM | LJP6 | 72 | hr | 513 | 397 | 10473 | 0.0379 | -0.0574 |
| MCF 10A | PD0325901 | 10 | uM | LJP6 | 72 | hr | 513 | 398 | 10473 | 0.0380 | -0.0571 |
| MDA-MB-231 | Celastrol | 10 | uM | LJP6 | 72 | hr | 868 | 402 | 3556 | 0.1136 | -0.3153 |
| MCF 10A | CGP60474 | 10 | uM | LJP6 | 72 | hr | 513 | 402 | 10473 | 0.0384 | -0.0616 |
| MCF 10A | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 513 | 403 | 10362 | 0.0389 | -0.0545 |
| MCF 10A | SNS-032 | 10 | uM | LJP6 | 72 | hr | 513 | 407 | 10473 | 0.0389 | -0.0534 |
| MCF 10A | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 513 | 407 | 10473 | 0.0389 | -0.0529 |
| MCF7 | Mitoxantrone | 10 | uM | LJP6 | 72 | hr | 1235 | 408 | 4056 | 0.1006 | -0.4766 |
| MCF 10A | Dasatinib | 1.11 | uM | LJP6 | 72 | hr | 513 | 410 | 10473 | 0.0392 | -0.0505 |
| Hs 578T | Withaferin A | 10 | uM | LJP6 | 72 | hr | 929 | 411 | 3216 | 0.1277 | -0.3680 |
| MCF 10A | A443654 | 10 | uM | LJP6 | 72 | hr | 513 | 415 | 10473 | 0.0397 | -0.0489 |
| MCF 10A | Radicicol | 10 | uM | LJP6 | 72 | hr | 513 | 419 | 10473 | 0.0400 | -0.0461 |
| MCF7 | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 1235 | 420 | 4267 | 0.0987 | -0.4544 |
| MCF 10A | Afatinib | 0.12 | uM | LJP6 | 72 | hr | 513 | 427 | 10473 | 0.0408 | -0.0420 |
| MCF7 | Canertinib | 10 | uM | LJP6 | 72 | hr | 1235 | 430 | 4056 | 0.1061 | -0.4595 |
| MCF 10A | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 513 | 431 | 10473 | 0.0412 | -0.0395 |
| Hs 578T | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 929 | 442 | 3237 | 0.1366 | -0.3389 |