LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 551 | 4056 | 0.1358 | -0.3756 |
| MCF7 | Geldanamycin | 10 | uM | LJP6 | 72 | hr | 1235 | 552 | 4056 | 0.1361 | -0.3753 |
| SK-BR-3 | AZD 5438 | 10 | uM | LJP6 | 72 | hr | 1476 | 807 | 3643 | 0.2211 | -0.3737 |
| SK-BR-3 | HG-6-64-01 | 10 | uM | LJP6 | 72 | hr | 1476 | 809 | 3643 | 0.2232 | -0.3703 |
| Hs 578T | Withaferin A | 10 | uM | LJP6 | 72 | hr | 929 | 411 | 3216 | 0.1277 | -0.3680 |
| MCF7 | SNS-032 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 565 | 4056 | 0.1396 | -0.3669 |
| SK-BR-3 | SNS-032 | 10 | uM | LJP6 | 72 | hr | 1476 | 823 | 3643 | 0.2260 | -0.3633 |
| MCF7 | SNS-032 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 574 | 4056 | 0.1415 | -0.3617 |
| MCF7 | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 573 | 4056 | 0.1413 | -0.3613 |
| MCF7 | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 579 | 4056 | 0.1425 | -0.3583 |
| SK-BR-3 | Withaferin A | 3.33 | uM | LJP6 | 72 | hr | 1476 | 834 | 3643 | 0.2292 | -0.3564 |
| MCF7 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 584 | 4056 | 0.1442 | -0.3553 |
| BT-20 | GSK1059615 | 10 | uM | LJP5 | 72 | hr | 1657 | 772 | 5588 | 0.1384 | -0.3536 |
| MCF7 | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 1235 | 587 | 4056 | 0.1448 | -0.3520 |
| SK-BR-3 | GSK1059615 | 10 | uM | LJP6 | 72 | hr | 1476 | 843 | 3643 | 0.2315 | -0.3515 |
| SK-BR-3 | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 843 | 3643 | 0.2314 | -0.3514 |
| BT-20 | QL-XII-47 | 10 | uM | LJP6 | 72 | hr | 1657 | 799 | 5383 | 0.1487 | -0.3496 |
| MCF7 | LDN-193189 | 10 | uM | LJP5 | 72 | hr | 1235 | 573 | 4267 | 0.1346 | -0.3496 |
| MCF7 | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 592 | 4056 | 0.1461 | -0.3491 |
| SK-BR-3 | CGP60474 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 852 | 3643 | 0.2335 | -0.3474 |
| SK-BR-3 | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 1476 | 829 | 3772 | 0.2199 | -0.3472 |
| MCF7 | SNS-032 | 10 | uM | LJP6 | 72 | hr | 1235 | 598 | 4056 | 0.1476 | -0.3446 |
| MCF7 | CGP60474 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 604 | 4056 | 0.1487 | -0.3425 |
| SK-BR-3 | Alvocidib | 10 | uM | LJP6 | 72 | hr | 1476 | 861 | 3643 | 0.2372 | -0.3403 |
| Hs 578T | Mitoxantrone | 10 | uM | LJP5 | 72 | hr | 929 | 442 | 3237 | 0.1366 | -0.3389 |