LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 10 of 15: Cell count and normalized growth rate inhibition values within biological replicate 3. - Dataset (ID:20247)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Replicate Assay Well Timepoint Timepoint Unit Total Cell Count Before Treatment Total Cell Count After Treatment Total Control Cell Count Relative Cell Count Normalized Growth Rate Inhibition Value
MDA-MB-231 Trametinib
3.33
uM
LJP5
 3
P20
 72
hr
 1235 1347 4929 0.2733 0.0441
MDA-MB-231 Trametinib
10
uM
LJP5
 1
P19
 72
hr
 1235 1148 4474 0.2566 -0.0390
MDA-MB-231 Trametinib
10
uM
LJP5
 2
P19
 72
hr
 1235 1240 4578 0.2708 0.0017
MDA-MB-231 Trametinib
10
uM
LJP5
 3
P19
 72
hr
 1235 1469 4929 0.2980 0.0904
MDA-MB-231 Omipalisib
0.04
uM
LJP6
 1
N06
 72
hr
 1235 1857 4355 0.4263 0.2511
MDA-MB-231 Omipalisib
0.04
uM
LJP6
 2
N06
 72
hr
 1235 1952 4277 0.4564 0.2907
MDA-MB-231 Omipalisib
0.04
uM
LJP6
 3
N06
 72
hr
 1235 2201 4583 0.4802 0.3569
MDA-MB-231 Omipalisib
0.12
uM
LJP6
 1
N05
 72
hr
 1235 1585 4355 0.3639 0.1467
MDA-MB-231 Omipalisib
0.12
uM
LJP6
 2
N05
 72
hr
 1235 1446 4277 0.3381 0.0916
MDA-MB-231 Omipalisib
0.12
uM
LJP6
 3
N05
 72
hr
 1235 1525 4583 0.3327 0.1176
MDA-MB-231 Omipalisib
0.37
uM
LJP6
 1
N04
 72
hr
 1235 1141 4355 0.2619 -0.0430
MDA-MB-231 Omipalisib
0.37
uM
LJP6
 2
N04
 72
hr
 1235 1118 4277 0.2614 -0.0545
MDA-MB-231 Omipalisib
0.37
uM
LJP6
 3
N04
 72
hr
 1235 1208 4583 0.2636 -0.0120
MDA-MB-231 Omipalisib
1.11
uM
LJP6
 1
N03
 72
hr
 1235 947 4355 0.2174 -0.1363
MDA-MB-231 Omipalisib
1.11
uM
LJP6
 2
N03
 72
hr
 1235 917 4277 0.2144 -0.1535
MDA-MB-231 Omipalisib
1.11
uM
LJP6
 3
N03
 72
hr
 1235 1035 4583 0.2258 -0.0896
MDA-MB-231 Omipalisib
3.33
uM
LJP6
 1
N02
 72
hr
 1235 805 4355 0.1848 -0.2102
MDA-MB-231 Omipalisib
3.33
uM
LJP6
 2
N02
 72
hr
 1235 826 4277 0.1931 -0.2015
MDA-MB-231 Omipalisib
3.33
uM
LJP6
 3
N02
 72
hr
 1235 842 4583 0.1837 -0.1837
MDA-MB-231 Omipalisib
10
uM
LJP6
 1
N01
 72
hr
 1235 701 4355 0.1609 -0.2681
MDA-MB-231 Omipalisib
10
uM
LJP6
 2
N01
 72
hr
 1235 687 4277 0.1606 -0.2796
MDA-MB-231 Omipalisib
10
uM
LJP6
 3
N01
 72
hr
 1235 781 4583 0.1704 -0.2156
MDA-MB-231 Buparlisib
0.04
uM
LJP5
 1
H06
 72
hr
 1235 4624 4474 1.0334 1.0357
MDA-MB-231 Buparlisib
0.04
uM
LJP5
 2
H06
 72
hr
 1235 4615 4578 1.0080 1.0084
MDA-MB-231 Buparlisib
0.04
uM
LJP5
 3
H06
 72
hr
 1235 4661 4929 0.9456 0.9447