LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 10 of 15: Cell count and normalized growth rate inhibition values within biological replicate 3. - Dataset (ID:20247)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Replicate Assay Well Timepoint Timepoint Unit Total Cell Count Before Treatment Total Cell Count After Treatment Total Control Cell Count Relative Cell Count Normalized Growth Rate Inhibition Value
MDA-MB-231 Fedratinib
0.37
uM
LJP5
 2
L04
 72
hr
 1235 3500 4578 0.7644 0.7349
MDA-MB-231 Fedratinib
0.37
uM
LJP5
 3
L04
 72
hr
 1235 4371 4929 0.8867 0.8831
MDA-MB-231 Fedratinib
1.11
uM
LJP5
 1
L03
 72
hr
 1235 2379 4474 0.5317 0.4230
MDA-MB-231 Fedratinib
1.11
uM
LJP5
 2
L03
 72
hr
 1235 2470 4578 0.5395 0.4426
MDA-MB-231 Fedratinib
1.11
uM
LJP5
 3
L03
 72
hr
 1235 2884 4929 0.5851 0.5289
MDA-MB-231 Fedratinib
3.33
uM
LJP5
 1
L02
 72
hr
 1235 1002 4474 0.2239 -0.1069
MDA-MB-231 Fedratinib
3.33
uM
LJP5
 2
L02
 72
hr
 1235 1146 4578 0.2503 -0.0392
MDA-MB-231 Fedratinib
3.33
uM
LJP5
 3
L02
 72
hr
 1235 1161 4929 0.2355 -0.0309
MDA-MB-231 Fedratinib
10
uM
LJP5
 1
L01
 72
hr
 1235 379 4474 0.0847 -0.4710
MDA-MB-231 Fedratinib
10
uM
LJP5
 2
L01
 72
hr
 1235 297 4578 0.0649 -0.5299
MDA-MB-231 Fedratinib
10
uM
LJP5
 3
L01
 72
hr
 1235 518 4929 0.1051 -0.3532
MDA-MB-231 Trametinib
0.04
uM
LJP5
 1
P24
 72
hr
 1235 1366 4474 0.3053 0.0554
MDA-MB-231 Trametinib
0.04
uM
LJP5
 2
P24
 72
hr
 1235 1288 4578 0.2813 0.0221
MDA-MB-231 Trametinib
0.04
uM
LJP5
 3
P24
 72
hr
 1235 1375 4929 0.2790 0.0549
MDA-MB-231 Trametinib
0.12
uM
LJP5
 1
P23
 72
hr
 1235 1273 4474 0.2845 0.0160
MDA-MB-231 Trametinib
0.12
uM
LJP5
 2
P23
 72
hr
 1235 1212 4578 0.2647 -0.0103
MDA-MB-231 Trametinib
0.12
uM
LJP5
 3
P23
 72
hr
 1235 1334 4929 0.2706 0.0390
MDA-MB-231 Trametinib
0.37
uM
LJP5
 1
P22
 72
hr
 1235 1306 4474 0.2919 0.0301
MDA-MB-231 Trametinib
0.37
uM
LJP5
 2
P22
 72
hr
 1235 1307 4578 0.2855 0.0300
MDA-MB-231 Trametinib
0.37
uM
LJP5
 3
P22
 72
hr
 1235 1375 4929 0.2790 0.0549
MDA-MB-231 Trametinib
1.11
uM
LJP5
 1
P21
 72
hr
 1235 1246 4474 0.2785 0.0044
MDA-MB-231 Trametinib
1.11
uM
LJP5
 2
P21
 72
hr
 1235 1257 4578 0.2745 0.0090
MDA-MB-231 Trametinib
1.11
uM
LJP5
 3
P21
 72
hr
 1235 1412 4929 0.2865 0.0690
MDA-MB-231 Trametinib
3.33
uM
LJP5
 1
P20
 72
hr
 1235 1210 4474 0.2704 -0.0114
MDA-MB-231 Trametinib
3.33
uM
LJP5
 2
P20
 72
hr
 1235 1270 4578 0.2774 0.0145