LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 513 | 374 | 10401 | 0.0360 | -0.0140 |
| MCF7 | AZD 5438 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 381 | 4156 | 0.0917 | -0.2925 |
| MCF7 | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 383 | 4156 | 0.0922 | -0.2917 |
| MCF 10A | TWS119 | 10.0 | uM | LJP5 | 72 | hr | 513 | 385 | 10401 | 0.0371 | -0.0129 |
| MCF 10A | Buparlisib | 3.33 | uM | LJP5 | 72 | hr | 513 | 386 | 10401 | 0.0371 | -0.0129 |
| MCF 10A | Mitoxantrone | 1.11 | uM | LJP5 | 72 | hr | 513 | 387 | 10401 | 0.0372 | -0.0128 |
| MCF 10A | Geldanamycin | 3.33 | uM | LJP5 | 72 | hr | 513 | 389 | 10401 | 0.0374 | -0.0125 |
| MCF 10A | Geldanamycin | 3.33 | uM | LJP6 | 72 | hr | 513 | 393 | 10401 | 0.0378 | -0.0122 |
| MCF 10A | Omipalisib | 10.0 | uM | LJP6 | 72 | hr | 513 | 397 | 10401 | 0.0382 | -0.0117 |
| MCF 10A | PD0325901 | 10.0 | uM | LJP6 | 72 | hr | 513 | 398 | 10401 | 0.0383 | -0.0117 |
| MCF 10A | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 513 | 402 | 10401 | 0.0387 | -0.0113 |
| MDA-MB-231 | Celastrol | 10.0 | uM | LJP6 | 72 | hr | 868 | 402 | 3486 | 0.1155 | -0.1778 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 513 | 403 | 10401 | 0.0387 | -0.0112 |
| MCF 10A | Mitoxantrone | 3.33 | uM | LJP6 | 72 | hr | 513 | 407 | 10401 | 0.0391 | -0.0108 |
| MCF 10A | SNS-032 | 10.0 | uM | LJP6 | 72 | hr | 513 | 407 | 10401 | 0.0391 | -0.0108 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1235 | 408 | 4156 | 0.0982 | -0.2833 |
| MCF 10A | Dasatinib | 1.11 | uM | LJP6 | 72 | hr | 513 | 410 | 10401 | 0.0395 | -0.0104 |
| Hs 578T | Withaferin A | 10.0 | uM | LJP6 | 72 | hr | 929 | 411 | 3228 | 0.1274 | -0.2253 |
| MCF 10A | A443654 | 10.0 | uM | LJP6 | 72 | hr | 513 | 415 | 10401 | 0.0400 | -0.0099 |
| MCF 10A | Radicicol | 10.0 | uM | LJP6 | 72 | hr | 513 | 419 | 10401 | 0.0403 | -0.0095 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1235 | 420 | 4156 | 0.1011 | -0.2791 |
| MCF 10A | Afatinib | 0.12 | uM | LJP6 | 72 | hr | 513 | 427 | 10401 | 0.0411 | -0.0087 |
| MCF7 | Canertinib | 10.0 | uM | LJP6 | 72 | hr | 1235 | 430 | 4156 | 0.1035 | -0.2756 |
| MCF 10A | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 513 | 431 | 10401 | 0.0414 | -0.0083 |
| Hs 578T | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 929 | 442 | 3228 | 0.1369 | -0.2120 |