LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Withaferin A | 10.0 | uM | LJP6 | 72 | hr | 929 | 411 | 3228 | 0.1274 | -0.2253 |
| SK-BR-3 | Nintedanib | 10.0 | uM | LJP6 | 72 | hr | 1476 | 977 | 3694 | 0.2646 | -0.2252 |
| MCF7 | SNS-032 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 579 | 4156 | 0.1393 | -0.2247 |
| SK-BR-3 | Alvocidib | 1.11 | uM | LJP6 | 72 | hr | 1476 | 981 | 3694 | 0.2656 | -0.2236 |
| BT-20 | QL-XII-47 | 10.0 | uM | LJP6 | 72 | hr | 1657 | 799 | 5505 | 0.1452 | -0.2231 |
| MCF7 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 584 | 4156 | 0.1405 | -0.2230 |
| SK-BR-3 | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 983 | 3694 | 0.2661 | -0.2227 |
| MCF7 | CGP60474 | 0.12 | uM | LJP6 | 72 | hr | 1235 | 587 | 4156 | 0.1413 | -0.2219 |
| MDA-MB-231 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 868 | 290 | 3486 | 0.0832 | -0.2208 |
| SK-BR-3 | A443654 | 10.0 | uM | LJP6 | 72 | hr | 1476 | 988 | 3694 | 0.2675 | -0.2204 |
| MCF7 | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 1235 | 592 | 4156 | 0.1426 | -0.2201 |
| SK-BR-3 | Withaferin A | 10.0 | uM | LJP6 | 72 | hr | 1476 | 989 | 3694 | 0.2677 | -0.2200 |
| SK-BR-3 | CGP60474 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 992 | 3694 | 0.2685 | -0.2186 |
| MCF7 | SNS-032 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 598 | 4156 | 0.1440 | -0.2180 |
| MCF7 | CGP60474 | 0.04 | uM | LJP6 | 72 | hr | 1235 | 604 | 4156 | 0.1453 | -0.2162 |
| SK-BR-3 | Mitoxantrone | 3.33 | uM | LJP5 | 72 | hr | 1476 | 998 | 3694 | 0.2703 | -0.2156 |
| SK-BR-3 | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 999 | 3694 | 0.2704 | -0.2155 |
| SK-BR-3 | AZD7762 | 10.0 | uM | LJP6 | 72 | hr | 1476 | 1002 | 3694 | 0.2713 | -0.2139 |
| SK-BR-3 | Celastrol | 10.0 | uM | LJP6 | 72 | hr | 1476 | 1002 | 3694 | 0.2714 | -0.2138 |
| BT-20 | AZD7762 | 10.0 | uM | LJP6 | 72 | hr | 1657 | 836 | 5505 | 0.1519 | -0.2135 |
| BT-20 | GSK1059615 | 10.0 | uM | LJP6 | 72 | hr | 1657 | 837 | 5505 | 0.1520 | -0.2133 |
| SK-BR-3 | AZD7762 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1004 | 3694 | 0.2720 | -0.2129 |
| SK-BR-3 | SNS-032 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 1006 | 3694 | 0.2724 | -0.2121 |
| SK-BR-3 | Canertinib | 10.0 | uM | LJP6 | 72 | hr | 1476 | 1006 | 3694 | 0.2724 | -0.2121 |
| Hs 578T | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 929 | 442 | 3228 | 0.1369 | -0.2120 |