LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Torin2 | 0.12 | uM | LJP5 | 72 | hr | 1657 | 1522 | 5505 | 0.2766 | -0.0351 |
| Hs 578T | CGP60474 | 0.37 | uM | LJP6 | 72 | hr | 929 | 849 | 3228 | 0.2631 | -0.0348 |
| MDA-MB-231 | Dasatinib | 0.04 | uM | LJP6 | 72 | hr | 868 | 777 | 3486 | 0.2229 | -0.0348 |
| BT-20 | Radicicol | 10.0 | uM | LJP6 | 72 | hr | 1657 | 1525 | 5505 | 0.2770 | -0.0345 |
| BT-20 | Foretinib | 10.0 | uM | LJP5 | 72 | hr | 1657 | 1525 | 5505 | 0.2771 | -0.0344 |
| Hs 578T | GSK1059615 | 10.0 | uM | LJP6 | 72 | hr | 929 | 852 | 3228 | 0.2639 | -0.0336 |
| Hs 578T | Alvocidib | 0.12 | uM | LJP6 | 72 | hr | 929 | 852 | 3228 | 0.2641 | -0.0333 |
| MDA-MB-231 | GSK1059615 | 3.33 | uM | LJP5 | 72 | hr | 868 | 781 | 3486 | 0.2240 | -0.0333 |
| MCF7 | Torin1 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 1138 | 4156 | 0.2739 | -0.0332 |
| SK-BR-3 | Canertinib | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1403 | 3694 | 0.3799 | -0.0331 |
| Hs 578T | AZD7762 | 3.33 | uM | LJP6 | 72 | hr | 929 | 853 | 3228 | 0.2644 | -0.0330 |
| SK-BR-3 | QL-XII-47 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1403 | 3694 | 0.3800 | -0.0329 |
| MDA-MB-231 | SNS-032 | 10.0 | uM | LJP6 | 72 | hr | 868 | 782 | 3486 | 0.2244 | -0.0328 |
| SK-BR-3 | BX-912 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 1405 | 3694 | 0.3804 | -0.0322 |
| Hs 578T | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 929 | 855 | 3228 | 0.2650 | -0.0322 |
| MCF7 | PHA-793887 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1143 | 4156 | 0.2751 | -0.0315 |
| MCF7 | Torin2 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 1143 | 4156 | 0.2752 | -0.0314 |
| SK-BR-3 | PF477736 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1407 | 3694 | 0.3810 | -0.0313 |
| SK-BR-3 | PF477736 | 1.11 | uM | LJP5 | 72 | hr | 1476 | 1409 | 3694 | 0.3815 | -0.0304 |
| BT-20 | CGP60474 | 0.37 | uM | LJP5 | 72 | hr | 1657 | 1541 | 5505 | 0.2800 | -0.0303 |
| SK-BR-3 | PF477736 | 10.0 | uM | LJP5 | 72 | hr | 1476 | 1410 | 3694 | 0.3817 | -0.0301 |
| MCF 10A | Dasatinib | 10.0 | uM | LJP6 | 72 | hr | 513 | 217 | 10401 | 0.0209 | -0.0300 |
| MCF7 | PI103 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 1148 | 4156 | 0.2762 | -0.0299 |
| BT-20 | ZSTK474 | 10.0 | uM | LJP6 | 72 | hr | 1657 | 1543 | 5505 | 0.2803 | -0.0297 |
| BT-20 | BI-2536 | 0.37 | uM | LJP6 | 72 | hr | 1657 | 1544 | 5505 | 0.2804 | -0.0296 |