LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. - Dataset (ID:20240)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Omipalisib | 1.11 | uM | LJP6 | 72 | hr | 1657 | 1187 | 5505 | 0.2157 | -0.1223 |
| BT-20 | Alvocidib | 3.33 | uM | LJP6 | 72 | hr | 1657 | 1188 | 5505 | 0.2158 | -0.1220 |
| MCF7 | HG-5-113-01 | 10.0 | uM | LJP5 | 72 | hr | 1235 | 883 | 4156 | 0.2125 | -0.1207 |
| MDA-MB-231 | AT-7519 | 10.0 | uM | LJP6 | 72 | hr | 868 | 553 | 3486 | 0.1586 | -0.1204 |
| MCF7 | WZ3105 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 883 | 4156 | 0.2126 | -0.1204 |
| BT-20 | SNS-032 | 0.37 | uM | LJP6 | 72 | hr | 1657 | 1197 | 5505 | 0.2175 | -0.1196 |
| MDA-MB-231 | Geldanamycin | 10.0 | uM | LJP6 | 72 | hr | 868 | 555 | 3486 | 0.1592 | -0.1196 |
| SK-BR-3 | Radicicol | 10.0 | uM | LJP5 | 72 | hr | 1476 | 1213 | 3694 | 0.3286 | -0.1186 |
| BT-20 | Pelitinib | 10.0 | uM | LJP5 | 72 | hr | 1657 | 1202 | 5505 | 0.2184 | -0.1183 |
| Hs 578T | Buparlisib | 10.0 | uM | LJP5 | 72 | hr | 929 | 657 | 3228 | 0.2036 | -0.1183 |
| MCF7 | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 1235 | 893 | 4156 | 0.2149 | -0.1171 |
| MCF7 | WZ-4-145 | 10.0 | uM | LJP6 | 72 | hr | 1235 | 895 | 4156 | 0.2155 | -0.1163 |
| SK-BR-3 | Alvocidib | 0.12 | uM | LJP6 | 72 | hr | 1476 | 1219 | 3694 | 0.3302 | -0.1159 |
| SK-BR-3 | QL-X-138 | 10.0 | uM | LJP6 | 72 | hr | 1476 | 1220 | 3694 | 0.3304 | -0.1156 |
| SK-BR-3 | Dasatinib | 10.0 | uM | LJP5 | 72 | hr | 1476 | 1221 | 3694 | 0.3307 | -0.1150 |
| BT-20 | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 1657 | 1217 | 5505 | 0.2210 | -0.1145 |
| BT-20 | CGP60474 | 0.04 | uM | LJP6 | 72 | hr | 1657 | 1217 | 5505 | 0.2211 | -0.1145 |
| BT-20 | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 1657 | 1218 | 5505 | 0.2212 | -0.1143 |
| SK-BR-3 | Alvocidib | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1225 | 3694 | 0.3317 | -0.1134 |
| MCF7 | WZ3105 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 904 | 4156 | 0.2176 | -0.1133 |
| BT-20 | GSK1059615 | 1.11 | uM | LJP5 | 72 | hr | 1657 | 1221 | 5505 | 0.2219 | -0.1133 |
| Hs 578T | CGP60474 | 10.0 | uM | LJP6 | 72 | hr | 929 | 669 | 3228 | 0.2074 | -0.1131 |
| BT-20 | GDC-0980 | 10.0 | uM | LJP5 | 72 | hr | 1657 | 1222 | 5505 | 0.2221 | -0.1131 |
| MDA-MB-231 | A443654 | 3.33 | uM | LJP6 | 72 | hr | 868 | 572 | 3486 | 0.1641 | -0.1131 |
| MDA-MB-231 | Y39983 | 10.0 | uM | LJP6 | 72 | hr | 868 | 573 | 3486 | 0.1644 | -0.1127 |