LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 1 of 15: Cell count and relative growth within biological replicate 1. - Dataset (ID:20237)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Replicate | Assay Well | Timepoint | Timepoint Unit | Total Cell Count Before Treatment | Total Cell Count After Treatment | Total Control Cell Count | Relative Cell Count | Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Lapatinib | 10.0 | uM | LJP6 | 3 | M19 | 72 | hr | 513 | 613 | 10401 | 0.0589 | 0.0101 |
| MCF 10A | LDN-193189 | 10.0 | uM | LJP5 | 1 | G01 | 72 | hr | 513 | 130 | 10401 | 0.0125 | -0.0388 |
| MCF 10A | LDN-193189 | 10.0 | uM | LJP5 | 2 | G01 | 72 | hr | 513 | 153 | 10401 | 0.0147 | -0.0364 |
| MCF 10A | LDN-193189 | 10.0 | uM | LJP5 | 3 | G01 | 72 | hr | 513 | 114 | 10401 | 0.0110 | -0.0404 |
| MCF 10A | Linifanib | 10.0 | uM | LJP6 | 1 | J07 | 72 | hr | 513 | 2860 | 10401 | 0.2750 | 0.2373 |
| MCF 10A | Linifanib | 10.0 | uM | LJP6 | 2 | J07 | 72 | hr | 513 | 2616 | 10401 | 0.2515 | 0.2127 |
| MCF 10A | Linifanib | 10.0 | uM | LJP6 | 3 | J07 | 72 | hr | 513 | 2074 | 10401 | 0.1994 | 0.1578 |
| MCF 10A | Linsitinib | 10.0 | uM | LJP5 | 1 | O19 | 72 | hr | 513 | 1843 | 10401 | 0.1772 | 0.1345 |
| MCF 10A | Linsitinib | 10.0 | uM | LJP5 | 2 | O19 | 72 | hr | 513 | 2144 | 10401 | 0.2061 | 0.1649 |
| MCF 10A | Linsitinib | 10.0 | uM | LJP5 | 3 | O19 | 72 | hr | 513 | 2054 | 10401 | 0.1975 | 0.1558 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP5 | 1 | C19 | 72 | hr | 513 | 403 | 10401 | 0.0387 | -0.0112 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP5 | 2 | C19 | 72 | hr | 513 | 379 | 10401 | 0.0364 | -0.0136 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP5 | 3 | C19 | 72 | hr | 513 | 427 | 10401 | 0.0411 | -0.0087 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP6 | 1 | C19 | 72 | hr | 513 | 449 | 10401 | 0.0432 | -0.0065 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP6 | 2 | C19 | 72 | hr | 513 | 451 | 10401 | 0.0434 | -0.0063 |
| MCF 10A | Mitoxantrone | 10.0 | uM | LJP6 | 3 | C19 | 72 | hr | 513 | 492 | 10401 | 0.0473 | -0.0022 |
| MCF 10A | MK2206 | 10.0 | uM | LJP6 | 1 | F01 | 72 | hr | 513 | 1990 | 10401 | 0.1913 | 0.1493 |
| MCF 10A | MK2206 | 10.0 | uM | LJP6 | 2 | F01 | 72 | hr | 513 | 2118 | 10401 | 0.2036 | 0.1623 |
| MCF 10A | MK2206 | 10.0 | uM | LJP6 | 3 | F01 | 72 | hr | 513 | 2081 | 10401 | 0.2001 | 0.1585 |
| MCF 10A | Neratinib | 10.0 | uM | LJP5 | 1 | A13 | 72 | hr | 513 | 571 | 10401 | 0.0549 | 0.0058 |
| MCF 10A | Neratinib | 10.0 | uM | LJP5 | 2 | A13 | 72 | hr | 513 | 637 | 10401 | 0.0612 | 0.0125 |
| MCF 10A | Neratinib | 10.0 | uM | LJP5 | 3 | A13 | 72 | hr | 513 | 785 | 10401 | 0.0755 | 0.0275 |
| MCF 10A | Nilotinib | 10.0 | uM | LJP5 | 1 | N13 | 72 | hr | 513 | 3889 | 10401 | 0.3739 | 0.3414 |
| MCF 10A | Nilotinib | 10.0 | uM | LJP5 | 2 | N13 | 72 | hr | 513 | 4406 | 10401 | 0.4236 | 0.3937 |
| MCF 10A | Nilotinib | 10.0 | uM | LJP5 | 3 | N13 | 72 | hr | 513 | 2998 | 10401 | 0.2882 | 0.2513 |