PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| MMAC-SF | avg(48,72) | hr | Viability | 4.97490 | 1.04360 |
| WM-115 | avg(48,72) | hr | Viability | 4.24100 | 2.15740 |
| SKMEL28 | avg(48,72) | hr | Viability | 4.68090 | 1.33340 |
| MZ7-mel | avg(48,72) | hr | Viability | 4.96100 | 1.18220 |
| C32 | avg(48,72) | hr | Viability | 4.86600 | 1.54590 |
| COLO 858 | avg(48,72) | hr | Viability | 5.04880 | 0.60826 |
| LOXIMVI | avg(48,72) | hr | Viability | 3.53370 | 2.20440 |
| RVH-421 | avg(48,72) | hr | Viability | 4.97890 | 0.83992 |
| WM1552C | avg(48,72) | hr | Viability | 4.89960 | 1.35020 |
| C32 | 5 | hr | p-Histone H3(S10) | -1.16240 | 0.38982 |
| C32 | 5 | hr | p-p90RSK(T573) | -0.50929 | -0.16568 |
| C32 | 5 | hr | Bim | -0.88685 | -0.00581 |
| C32 | 5 | hr | p27 Kip1 | -0.32568 | -0.29943 |
| C32 | 5 | hr | cPARP | 0.19076 | -0.14485 |
| COLO 858 | 5 | hr | pMEK(S217/221) | 2.16380 | 1.40920 |
| COLO 858 | 5 | hr | pERK(T202/Y204) | 6.41020 | -2.35040 |
| C32 | 5 | hr | p-P38(T180/Y182) | -0.04272 | -0.22597 |
| C32 | 5 | hr | Total c-Jun | 2.01540 | -0.30253 |
| C32 | 5 | hr | p-JNK(T183/Y185) | 0.00978 | -0.94781 |
| C32 | 5 | hr | p-cJun(S63) | NaN | NaN |
| C32 | 5 | hr | pMEK(S217/221) | 2.90920 | -1.19320 |
| C32 | 5 | hr | pERK(T202/Y204) | 6.85300 | 0.56211 |
| C32 | 5 | hr | p-p90RSK(S380) | NaN | NaN |
| C32 | 5 | hr | p-HSP27(S82) | NaN | NaN |
| C32 | 5 | hr | p-p70S6K(T389) | NaN | NaN |