PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| LOXIMVI | 48 | hr | pMEK(S217/221) | 0.80333 | -6.00350 |
| K2 | 48 | hr | pMEK(S217/221) | 2.71360 | -5.74430 |
| K2 | 10 | hr | pMEK(S217/221) | 6.04980 | -5.58850 |
| LOXIMVI | 24 | hr | pMEK(S217/221) | 0.77258 | -5.57340 |
| K2 | 1 | hr | pMEK(S217/221) | 5.45430 | -5.46910 |
| K2 | 24 | hr | pMEK(S217/221) | 3.57990 | -5.36320 |
| LOXIMVI | 10 | hr | pMEK(S217/221) | 1.48060 | -5.21470 |
| LOXIMVI | 1 | hr | pMEK(S217/221) | 1.90140 | -5.11530 |
| K2 | 5 | hr | pMEK(S217/221) | 4.26630 | -5.01600 |
| LOXIMVI | 5 | hr | pMEK(S217/221) | 0.53975 | -4.08460 |
| LOXIMVI | 1 | hr | pERK(T202/Y204) | 4.84600 | -3.07470 |
| SKMEL28 | 48 | hr | pMEK(S217/221) | 3.77550 | -3.05560 |
| SKMEL28 | 10 | hr | pMEK(S217/221) | 5.73860 | -3.04210 |
| SKMEL28 | 1 | hr | pMEK(S217/221) | 4.28700 | -3.02360 |
| SKMEL28 | 5 | hr | pMEK(S217/221) | 3.43520 | -2.98760 |
| SKMEL28 | 24 | hr | pMEK(S217/221) | 3.88260 | -2.85530 |
| LOXIMVI | 1 | hr | p-P38(T180/Y182) | 3.06110 | -2.68300 |
| MMAC-SF | 1 | hr | pMEK(S217/221) | 4.16280 | -2.59440 |
| COLO 858 | 48 | hr | pERK(T202/Y204) | 7.31020 | -2.40440 |
| COLO 858 | 5 | hr | pERK(T202/Y204) | 6.41020 | -2.35040 |
| RVH-421 | 1 | hr | pMEK(S217/221) | 6.98480 | -2.31590 |
| MMAC-SF | 10 | hr | pMEK(S217/221) | 4.18770 | -2.30410 |
| MZ7-mel | 5 | hr | pMEK(S217/221) | 2.78840 | -2.26900 |
| MMAC-SF | 48 | hr | pMEK(S217/221) | 4.31200 | -2.24210 |
| WM1552C | 24 | hr | p-AKT(T308) | -0.86416 | -2.22510 |