PLSR model loadings (pMEK and pERK included) from analysis of the covariation of molecular signals with cell viability and apoptosis fraction in BRAF(V600E/D) melanoma cell lines - Dataset (ID:20229)
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| Cell Line | Time Point | Time Point Unit | Variable | PC1 Loading | PC2 Loading |
|---|---|---|---|---|---|
| RVH-421 | 24 | hr | cPARP | -9.33010 | -1.03280 |
| RVH-421 | 48 | hr | cPARP | -7.05700 | -0.83344 |
| K2 | 48 | hr | p27 Kip1 | -6.35540 | -1.17370 |
| COLO 858 | 24 | hr | Bim | -6.02050 | -1.29730 |
| K2 | 48 | hr | Bim | -5.80920 | -0.89063 |
| COLO 858 | 24 | hr | p27 Kip1 | -5.50970 | -1.34610 |
| RVH-421 | 24 | hr | Total c-Jun | -5.50660 | 0.85027 |
| K2 | 24 | hr | Bim | -5.14450 | -0.22263 |
| RVH-421 | 48 | hr | Total c-Jun | -5.01050 | -1.27470 |
| K2 | 24 | hr | p27 Kip1 | -4.95450 | -0.40833 |
| MMAC-SF | 24 | hr | Bim | -4.87780 | -0.28308 |
| WM-115 | 48 | hr | Total c-Jun | -4.44870 | 1.66170 |
| K2 | 48 | hr | p-HSP27(S82) | -4.28960 | -0.14295 |
| K2 | 48 | hr | p-AKT(S473) | -4.07470 | -0.50698 |
| K2 | 48 | hr | p-cJun(S63) | -4.05810 | -0.20309 |
| SKMEL28 | 48 | hr | p27 Kip1 | -3.92110 | -1.28240 |
| K2 | 48 | hr | Total c-Jun | -3.83090 | -0.22865 |
| RVH-421 | 24 | hr | p27 Kip1 | -3.81390 | -1.51440 |
| MZ7-mel | 48 | hr | p27 Kip1 | -3.80790 | 0.37888 |
| K2 | 48 | hr | cPARP | -3.56130 | -0.67331 |
| MZ7-mel | 48 | hr | Bim | -3.54030 | 0.06996 |
| RVH-421 | 5 | hr | cPARP | -3.52540 | -1.15470 |
| MMAC-SF | 24 | hr | p27 Kip1 | -3.49340 | -0.71038 |
| K2 | 24 | hr | p-AKT(S473) | -3.44610 | 0.32810 |
| MZ7-mel | 24 | hr | p27 Kip1 | -3.44280 | -0.48346 |