Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 756.62 | p-Rb(S807/S811) | 56.61 | p-cJun(S73) | 22.24 | 2 | Colo858-signal3 | G5 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | Ki-67 | 1122.40 | p-Rb(S807/S811) | 98.57 | p-cJun(S73) | 31.92 | 2 | Colo858-signal3 | G6 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | Ki-67 | 1608.40 | p-Rb(S807/S811) | 136.81 | p-cJun(S73) | 31.60 | 2 | Colo858-signal3 | G7 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 2064.40 | p-Rb(S807/S811) | 152.34 | p-cJun(S73) | 26.96 | 2 | Colo858-signal3 | G8 |
| Vemurafenib | COLO 858 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | Ki-67 | 2282.60 | p-Rb(S807/S811) | 152.28 | p-cJun(S73) | 28.92 | 2 | Colo858-signal3 | G9 |
| Vemurafenib | LOXIMVI | 0.0033 | uM | 24 | hr | | p27 Kip1 | 339.87 | p-Rb(S807/S811) | 207.46 | p-ERK(T202/Y204) | 188.18 | 1 | LOXIMVI-signal1 | B10 | |
| Vemurafenib | LOXIMVI | 0.0000 | uM | 24 | hr | | p27 Kip1 | 346.49 | p-Rb(S807/S811) | 215.22 | p-ERK(T202/Y204) | 215.11 | 1 | LOXIMVI-signal1 | B11 | |
| Vemurafenib | LOXIMVI | 5.0000 | uM | 24 | hr | | p27 Kip1 | 499.44 | p-Rb(S807/S811) | 81.11 | p-ERK(T202/Y204) | 31.87 | 1 | LOXIMVI-signal1 | B2 | |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | p27 Kip1 | 456.75 | p-Rb(S807/S811) | 94.75 | p-ERK(T202/Y204) | 28.87 | 1 | LOXIMVI-signal1 | B3 | |
| Vemurafenib | LOXIMVI | 0.8000 | uM | 24 | hr | | p27 Kip1 | 437.65 | p-Rb(S807/S811) | 139.21 | p-ERK(T202/Y204) | 46.29 | 1 | LOXIMVI-signal1 | B4 | |
| Vemurafenib | LOXIMVI | 0.3200 | uM | 24 | hr | | p27 Kip1 | 395.79 | p-Rb(S807/S811) | 157.15 | p-ERK(T202/Y204) | 59.04 | 1 | LOXIMVI-signal1 | B5 | |
| Vemurafenib | LOXIMVI | 0.1280 | uM | 24 | hr | | p27 Kip1 | 366.51 | p-Rb(S807/S811) | 180.61 | p-ERK(T202/Y204) | 84.29 | 1 | LOXIMVI-signal1 | B6 | |
| Vemurafenib | LOXIMVI | 0.0512 | uM | 24 | hr | | p27 Kip1 | 344.62 | p-Rb(S807/S811) | 191.81 | p-ERK(T202/Y204) | 94.25 | 1 | LOXIMVI-signal1 | B7 | |
| Vemurafenib | LOXIMVI | 0.0205 | uM | 24 | hr | | p27 Kip1 | 330.03 | p-Rb(S807/S811) | 203.83 | p-ERK(T202/Y204) | 137.92 | 1 | LOXIMVI-signal1 | B8 | |
| Vemurafenib | LOXIMVI | 0.0082 | uM | 24 | hr | | p27 Kip1 | 317.67 | p-Rb(S807/S811) | 200.59 | p-ERK(T202/Y204) | 170.43 | 1 | LOXIMVI-signal1 | B9 | |
| Vemurafenib | LOXIMVI | 0.0033 | uM | 24 | hr | | p27 Kip1 | 312.49 | p-Rb(S807/S811) | 203.40 | p-ERK(T202/Y204) | 185.08 | 2 | LOXIMVI-signal1 | C10 | |
| Vemurafenib | LOXIMVI | 0.0000 | uM | 24 | hr | | p27 Kip1 | 330.81 | p-Rb(S807/S811) | 208.35 | p-ERK(T202/Y204) | 212.82 | 2 | LOXIMVI-signal1 | C11 | |
| Vemurafenib | LOXIMVI | 5.0000 | uM | 24 | hr | | p27 Kip1 | 487.55 | p-Rb(S807/S811) | 84.67 | p-ERK(T202/Y204) | 31.63 | 2 | LOXIMVI-signal1 | C2 | |
| Vemurafenib | LOXIMVI | 2.0000 | uM | 24 | hr | | p27 Kip1 | 457.12 | p-Rb(S807/S811) | 91.96 | p-ERK(T202/Y204) | 30.10 | 2 | LOXIMVI-signal1 | C3 | |
| Vemurafenib | LOXIMVI | 0.8000 | uM | 24 | hr | | p27 Kip1 | 434.48 | p-Rb(S807/S811) | 132.48 | p-ERK(T202/Y204) | 43.96 | 2 | LOXIMVI-signal1 | C4 | |
| Vemurafenib | LOXIMVI | 0.3200 | uM | 24 | hr | | p27 Kip1 | 384.63 | p-Rb(S807/S811) | 153.53 | p-ERK(T202/Y204) | 56.47 | 2 | LOXIMVI-signal1 | C5 | |
| Vemurafenib | LOXIMVI | 0.1280 | uM | 24 | hr | | p27 Kip1 | 364.85 | p-Rb(S807/S811) | 178.03 | p-ERK(T202/Y204) | 76.08 | 2 | LOXIMVI-signal1 | C6 | |
| Vemurafenib | LOXIMVI | 0.0512 | uM | 24 | hr | | p27 Kip1 | 346.34 | p-Rb(S807/S811) | 184.23 | p-ERK(T202/Y204) | 94.79 | 2 | LOXIMVI-signal1 | C7 | |
| Vemurafenib | LOXIMVI | 0.0205 | uM | 24 | hr | | p27 Kip1 | 319.35 | p-Rb(S807/S811) | 195.10 | p-ERK(T202/Y204) | 133.04 | 2 | LOXIMVI-signal1 | C8 | |
| Vemurafenib | LOXIMVI | 0.0082 | uM | 24 | hr | | p27 Kip1 | 317.72 | p-Rb(S807/S811) | 203.25 | p-ERK(T202/Y204) | 167.85 | 2 | LOXIMVI-signal1 | C9 |