Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 180.39 | p-Rb(S807/S811) | 38.47 | p-S6(S235/S236 | 77.58 | 1 | WM115-signal2 | B5 | |
| Vemurafenib | WM-115 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 209.33 | p-Rb(S807/S811) | 53.83 | p-S6(S235/S236 | 130.34 | 1 | WM115-signal2 | B6 | |
| Vemurafenib | WM-115 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 208.23 | p-Rb(S807/S811) | 67.34 | p-S6(S235/S236 | 176.14 | 1 | WM115-signal2 | B7 | |
| Vemurafenib | WM-115 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 196.19 | p-Rb(S807/S811) | 67.83 | p-S6(S235/S236 | 199.48 | 1 | WM115-signal2 | B8 | |
| Vemurafenib | WM-115 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 249.39 | p-Rb(S807/S811) | 71.37 | p-S6(S235/S236 | 206.70 | 1 | WM115-signal2 | B9 | |
| Vemurafenib | WM-115 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 209.37 | p-Rb(S807/S811) | 65.40 | p-S6(S235/S236 | 188.91 | 2 | WM115-signal2 | C10 | |
| Vemurafenib | WM-115 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 197.62 | p-Rb(S807/S811) | 67.65 | p-S6(S235/S236 | 195.82 | 2 | WM115-signal2 | C11 | |
| Vemurafenib | WM-115 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 209.18 | p-Rb(S807/S811) | 48.45 | p-S6(S235/S236 | 30.86 | 2 | WM115-signal2 | C2 | |
| Vemurafenib | WM-115 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 210.36 | p-Rb(S807/S811) | 47.67 | p-S6(S235/S236 | 54.23 | 2 | WM115-signal2 | C3 | |
| Vemurafenib | WM-115 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 179.29 | p-Rb(S807/S811) | 38.89 | p-S6(S235/S236 | 65.75 | 2 | WM115-signal2 | C4 | |
| Vemurafenib | WM-115 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 148.64 | p-Rb(S807/S811) | 35.95 | p-S6(S235/S236 | 64.00 | 2 | WM115-signal2 | C5 | |
| Vemurafenib | WM-115 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 201.09 | p-Rb(S807/S811) | 53.27 | p-S6(S235/S236 | 128.83 | 2 | WM115-signal2 | C6 | |
| Vemurafenib | WM-115 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 217.58 | p-Rb(S807/S811) | 65.73 | p-S6(S235/S236 | 171.08 | 2 | WM115-signal2 | C7 | |
| Vemurafenib | WM-115 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 223.87 | p-Rb(S807/S811) | 68.58 | p-S6(S235/S236 | 185.38 | 2 | WM115-signal2 | C8 | |
| Vemurafenib | WM-115 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 248.41 | p-Rb(S807/S811) | 70.27 | p-S6(S235/S236 | 185.43 | 2 | WM115-signal2 | C9 | |
| JNK-IN-8 | WM-115 | 0.0033 | uM | 24 | hr | | p-Histone H3(S10) | 197.00 | p-Rb(S807/S811) | 65.37 | p-S6(S235/S236 | 186.60 | 1 | WM115-signal2 | D10 | |
| JNK-IN-8 | WM-115 | 0.0000 | uM | 24 | hr | | p-Histone H3(S10) | 228.85 | p-Rb(S807/S811) | 67.48 | p-S6(S235/S236 | 192.17 | 1 | WM115-signal2 | D11 | |
| JNK-IN-8 | WM-115 | 5.0000 | uM | 24 | hr | | p-Histone H3(S10) | 248.53 | p-Rb(S807/S811) | 77.96 | p-S6(S235/S236 | 209.55 | 1 | WM115-signal2 | D2 | |
| JNK-IN-8 | WM-115 | 2.0000 | uM | 24 | hr | | p-Histone H3(S10) | 238.07 | p-Rb(S807/S811) | 80.65 | p-S6(S235/S236 | 200.44 | 1 | WM115-signal2 | D3 | |
| JNK-IN-8 | WM-115 | 0.8000 | uM | 24 | hr | | p-Histone H3(S10) | 235.96 | p-Rb(S807/S811) | 79.36 | p-S6(S235/S236 | 186.75 | 1 | WM115-signal2 | D4 | |
| JNK-IN-8 | WM-115 | 0.3200 | uM | 24 | hr | | p-Histone H3(S10) | 205.29 | p-Rb(S807/S811) | 76.65 | p-S6(S235/S236 | 177.08 | 1 | WM115-signal2 | D5 | |
| JNK-IN-8 | WM-115 | 0.1280 | uM | 24 | hr | | p-Histone H3(S10) | 238.95 | p-Rb(S807/S811) | 79.96 | p-S6(S235/S236 | 176.83 | 1 | WM115-signal2 | D6 | |
| JNK-IN-8 | WM-115 | 0.0512 | uM | 24 | hr | | p-Histone H3(S10) | 224.01 | p-Rb(S807/S811) | 72.06 | p-S6(S235/S236 | 189.44 | 1 | WM115-signal2 | D7 | |
| JNK-IN-8 | WM-115 | 0.0205 | uM | 24 | hr | | p-Histone H3(S10) | 216.44 | p-Rb(S807/S811) | 71.32 | p-S6(S235/S236 | 187.08 | 1 | WM115-signal2 | D8 | |
| JNK-IN-8 | WM-115 | 0.0082 | uM | 24 | hr | | p-Histone H3(S10) | 222.98 | p-Rb(S807/S811) | 70.29 | p-S6(S235/S236 | 190.36 | 1 | WM115-signal2 | D9 |