Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| JNK-IN-8 | WM1552C | 0.3200 | uM | 24 | hr | | p27 Kip1 | 238.39 | p-Rb(S807/S811) | 107.84 | p-ERK(T202/Y204) | 264.88 | 2 | WM1552C-signal1 | E5 | |
| JNK-IN-8 | WM1552C | 0.1280 | uM | 24 | hr | | p27 Kip1 | 230.98 | p-Rb(S807/S811) | 107.78 | p-ERK(T202/Y204) | 265.42 | 2 | WM1552C-signal1 | E6 | |
| JNK-IN-8 | WM1552C | 0.0512 | uM | 24 | hr | | p27 Kip1 | 242.80 | p-Rb(S807/S811) | 108.49 | p-ERK(T202/Y204) | 267.00 | 2 | WM1552C-signal1 | E7 | |
| JNK-IN-8 | WM1552C | 0.0205 | uM | 24 | hr | | p27 Kip1 | 245.39 | p-Rb(S807/S811) | 107.49 | p-ERK(T202/Y204) | 270.03 | 2 | WM1552C-signal1 | E8 | |
| JNK-IN-8 | WM1552C | 0.0082 | uM | 24 | hr | | p27 Kip1 | 253.36 | p-Rb(S807/S811) | 110.29 | p-ERK(T202/Y204) | 263.12 | 2 | WM1552C-signal1 | E9 | |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 231.78 | p-Rb(S807/S811) | 102.69 | p-ERK(T202/Y204) | 234.80 | 1 | WM1552C-signal1 | F10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 239.37 | p-Rb(S807/S811) | 107.35 | p-ERK(T202/Y204) | 253.29 | 1 | WM1552C-signal1 | F11 |
| Vemurafenib | WM1552C | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p27 Kip1 | 397.69 | p-Rb(S807/S811) | 59.60 | p-ERK(T202/Y204) | 26.88 | 1 | WM1552C-signal1 | F2 |
| Vemurafenib | WM1552C | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 478.70 | p-Rb(S807/S811) | 48.18 | p-ERK(T202/Y204) | 22.45 | 1 | WM1552C-signal1 | F3 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 428.03 | p-Rb(S807/S811) | 51.23 | p-ERK(T202/Y204) | 26.59 | 1 | WM1552C-signal1 | F4 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p27 Kip1 | 343.75 | p-Rb(S807/S811) | 67.08 | p-ERK(T202/Y204) | 51.17 | 1 | WM1552C-signal1 | F5 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p27 Kip1 | 279.48 | p-Rb(S807/S811) | 87.64 | p-ERK(T202/Y204) | 117.21 | 1 | WM1552C-signal1 | F6 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p27 Kip1 | 268.49 | p-Rb(S807/S811) | 89.43 | p-ERK(T202/Y204) | 154.75 | 1 | WM1552C-signal1 | F7 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 248.11 | p-Rb(S807/S811) | 100.68 | p-ERK(T202/Y204) | 212.80 | 1 | WM1552C-signal1 | F8 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 256.65 | p-Rb(S807/S811) | 104.44 | p-ERK(T202/Y204) | 246.25 | 1 | WM1552C-signal1 | F9 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0033 | uM | 24 | hr | | p27 Kip1 | 249.58 | p-Rb(S807/S811) | 104.56 | p-ERK(T202/Y204) | 242.42 | 2 | WM1552C-signal1 | G10 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0000 | uM | 24 | hr | | p27 Kip1 | 251.50 | p-Rb(S807/S811) | 108.70 | p-ERK(T202/Y204) | 256.82 | 2 | WM1552C-signal1 | G11 |
| Vemurafenib | WM1552C | JNK-IN-8 | 5.0000 | uM | 24 | hr | | p27 Kip1 | 418.63 | p-Rb(S807/S811) | 52.14 | p-ERK(T202/Y204) | 23.96 | 2 | WM1552C-signal1 | G2 |
| Vemurafenib | WM1552C | JNK-IN-8 | 2.0000 | uM | 24 | hr | | p27 Kip1 | 479.59 | p-Rb(S807/S811) | 46.48 | p-ERK(T202/Y204) | 22.78 | 2 | WM1552C-signal1 | G3 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.8000 | uM | 24 | hr | | p27 Kip1 | 421.07 | p-Rb(S807/S811) | 53.69 | p-ERK(T202/Y204) | 24.84 | 2 | WM1552C-signal1 | G4 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.3200 | uM | 24 | hr | | p27 Kip1 | 336.58 | p-Rb(S807/S811) | 69.57 | p-ERK(T202/Y204) | 57.54 | 2 | WM1552C-signal1 | G5 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.1280 | uM | 24 | hr | | p27 Kip1 | 284.31 | p-Rb(S807/S811) | 88.80 | p-ERK(T202/Y204) | 123.78 | 2 | WM1552C-signal1 | G6 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0512 | uM | 24 | hr | | p27 Kip1 | 273.71 | p-Rb(S807/S811) | 96.01 | p-ERK(T202/Y204) | 160.08 | 2 | WM1552C-signal1 | G7 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0205 | uM | 24 | hr | | p27 Kip1 | 245.42 | p-Rb(S807/S811) | 98.27 | p-ERK(T202/Y204) | 209.11 | 2 | WM1552C-signal1 | G8 |
| Vemurafenib | WM1552C | JNK-IN-8 | 0.0082 | uM | 24 | hr | | p27 Kip1 | 241.65 | p-Rb(S807/S811) | 104.81 | p-ERK(T202/Y204) | 245.66 | 2 | WM1552C-signal1 | G9 |