Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset - HMS LINCS Database

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)

August 25, 2015: The data file for this dataset was updated to include additional DMSO control data that were inadvertently omitted from the original version. The Assay Protocol description of how experimental data were normalized to DMSO control data also was clarified (point 9).

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Small Molecule	Cell Line	Drug Concentration	Conc Unit	Time Point	Time Point Unit	Replicate	Scanner/Software	pMEK(S217/221)	Normalized Median pMEK(S217/221)	pERK(T202/Y204)	Normalized Median pERK(T202/Y204)	p-p90RSK(S380)	Normalized Median p-p90RSK(S380)	p-p90RSK(T573)	Normalized Median p-p90RSK(T573)	p-AKT(T308)	Normalized Median p-AKT(T308)	p-AKT(S473)	Normalized Median p-AKT(S473)	p-mTOR(S2448)	Normalized Median p-mTOR(S2448)	p-p70S6K(T421/S424)	Normalized Median p-p70S6K(T421/S424)	p-p70S6K(T389)	Normalized Median p-p70S6K(T389)	p-S6(S235/236)	Normalized Median p-S6(S235/236)	p-AMPK(T172)	Normalized Median p-AMPK(T172)	p-JNK(T183/Y185)	Normalized Median p-JNK(T183/Y185)	Total c-Jun	Normalized Median Total c-Jun	p-cJun(S63)	Normalized Median p-cJun(S63)	p-P38(T180/Y182)	Normalized Median p-P38(T180/Y182)	p-HSP27(S82)	Normalized Median p-HSP27(S82)	p-NFKB(S536)	Normalized Median p-NFKB(S536)	Bim	Normalized Median Bim	cPARP	Normalized Median cPARP	p-Histone H3(S10)	Normalized Median p-Histone H3(S10)	p27 Kip1	Normalized Median p27 Kip1
	MMAC-SF	0.0000	uM	48	hr	7	Odyssey/Microvigene	1.0881		1.9841		0.4739		0.2062				0.6289						0.5051		0.9091				0.9615		0.6024		0.4902		0.6369		0.1972		0.7407		0.4348		0.3677		0.9901		0.8130
	MMAC-SF	0.0000	uM	48	hr	7	Odyssey/Microvigene	1.2063		2.1930		0.4808		0.2304		0.3096		0.6849		0.9009				0.5051		0.8000		0.9524		1.0753		0.6536		0.5587				0.2262		0.7299		0.4329		0.4255		1.0142		0.8850
	MMAC-SF	0.0000	uM	48	hr	8	Odyssey/Microvigene	1.0000		2.7100		0.4739		0.2212		0.3247		0.6135		0.8403				0.5405		1.1390		0.8850		1.0341		0.6803		0.5128		0.5814		0.2174		0.6993		0.4975		0.4425		0.9709		0.7042
	MMAC-SF	0.0000	uM	48	hr	8	Odyssey/Microvigene	1.0320		2.4096		0.5076				0.3012		0.6024		0.9434				0.5000		1.1186		0.9091		1.0695		0.7143		0.5155		0.5747		0.2155		0.7407		0.4878		0.4405		1.0341		0.7092
	MMAC-SF	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.8130		1.6181		0.3663		0.2188		0.2232				0.6211				0.4255		0.8403		0.7692		0.6711		0.5291		0.4184		0.4926		0.2028		0.6849		0.4444		0.3175		0.8265		0.6024
	MMAC-SF	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.8333		1.4684		0.3650		0.2160		0.2532		0.5780		0.7194				0.4717		0.8850		0.8065		0.6993		0.5650		0.4310		0.4878		0.2053		0.7246		0.4202		0.3106		0.8929		0.6024
	MMAC-SF	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.9434		1.8975		0.3861		0.2174		0.2604		0.5952		0.6897				0.4292		0.8621		0.7246		0.8197		0.5495		0.4329		0.5051		0.2062		0.6803		0.4587		0.3521		0.8197		0.6667
	MMAC-SF	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.9524		1.7452		0.3718				0.2646		0.5917		0.7937				0.4546		0.8772		0.7634		0.8265		0.5714		0.4049		0.4926		0.2141		0.7042		0.4386		0.3509		0.8547		0.6711
	MMAC-SF	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.8403		1.5625		0.3521		0.2208		0.2331		0.5556		0.6289				0.4237		0.8000		0.6944		0.7634		0.5128		0.4049		0.4695		0.2179		0.7194		0.4444		0.2874		0.8000		0.6452
	MMAC-SF	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.9009		1.5723		0.3623		0.2212		0.2481		0.5780		0.7463				0.4717		0.8000		0.7353		0.7752		0.5587		0.4425		0.4808		0.2146		0.7246		0.4184		0.3012		0.8621		0.6173
SB590885	MZ7-mel	0.0032	uM	1	hr	1	InnoScan/Mapix	0.4065	0.1324	2.7778	0.5698	0.0549	1.0146	0.0916	0.3380	0.0734	1.5509	0.0799	1.0977	0.6944	0.8769	0.3663	0.5815	0.1342	1.6044	7.6923	1.1041	0.2101	1.0286	0.3497	1.4665	0.0587	1.0838	0.0873	1.0669	0.0713	0.8076	0.0684	0.7921	0.0851	0.6590	0.1103	0.9255	0.0437	0.3363	0.9524	0.0275	0.1572	1.0688
SB590885	MZ7-mel	0.0032	uM	1	hr	2	InnoScan/Mapix	0.3846	0.1324	2.9412	0.5698	0.0504	1.0146	0.0998	0.3380	0.0644	1.5509	0.0834	1.0977	0.8265	0.8769	0.3891	0.5815	0.1822	1.6044	8.3333	1.1041	0.2174	1.0286	0.3472	1.4665	0.0657	1.0838	0.0907	1.0669	0.0867	0.8076	0.0700	0.7921	0.0762	0.6590	0.1018	0.9255	0.0469	0.3363	0.9346	0.0275	0.1883	1.0688
SB590885	MZ7-mel	0.0032	uM	1	hr	3	InnoScan/Mapix	0.2584	0.1324	1.8868	0.5698	0.0394	1.0146	0.0823	0.3380	0.0629	1.5509	0.0759	1.0977	0.5917	0.8769		0.5815	0.1748	1.6044	7.6923	1.1041	0.1712	1.0286	0.1770	1.4665	0.0635	1.0838	0.0588	1.0669	0.0748	0.8076	0.0685	0.7921	0.0675	0.6590	0.0840	0.9255		0.3363	1.0204	0.0275	0.1269	1.0688
SB590885	MZ7-mel	0.0032	uM	1	hr	4	InnoScan/Mapix	0.4808	0.1324	2.7778	0.5698	0.0437	1.0146	0.0883	0.3380	0.0477	1.5509	0.0786	1.0977	0.6944	0.8769	0.3436	0.5815	0.2049	1.6044	7.1429	1.1041	0.2179	1.0286	0.3413	1.4665	0.0543	1.0838	0.0876	1.0669	0.0711	0.8076	0.0636	0.7921	0.0611	0.6590	0.0941	0.9255	0.0439	0.3363	1.1905	0.0275	0.1570	1.0688
SB590885	MZ7-mel	0.0032	uM	1	hr	5	InnoScan/Mapix	0.3367	0.1324	2.3256	0.5698	0.0443	1.0146	0.0776	0.3380	0.0824	1.5509	0.0689	1.0977	0.6329	0.8769	0.3521	0.5815	0.1658	1.6044	7.1429	1.1041	0.1560	1.0286	0.3068	1.4665	0.0520	1.0838	0.0805	1.0669	0.0880	0.8076	0.0712	0.7921	0.0709	0.6590	0.0873	0.9255	0.0420	0.3363	0.7143	0.0275	0.1739	1.0688
SB590885	MZ7-mel	0.0032	uM	1	hr	6	InnoScan/Mapix	0.3106	0.1324	2.1739	0.5698	0.0412	1.0146	0.0797	0.3380	0.0833	1.5509	0.0762	1.0977	0.7246	0.8769	0.3759	0.5815	0.1133	1.6044	7.1429	1.1041	0.1565	1.0286	0.2833	1.4665	0.0623	1.0838	0.0848	1.0669	0.0935	0.8076	0.0651	0.7921	0.0650	0.6590	0.0835	0.9255	0.0411	0.3363	0.6849	0.0275	0.2268	1.0688
SB590885	MZ7-mel	0.0032	uM	1	hr	7	InnoScan/Mapix	0.2667	0.1324	1.8868	0.5698	0.0441	1.0146	0.0766	0.3380	0.1350	1.5509	0.0707	1.0977	0.5882	0.8769	0.3205	0.5815	0.0956	1.6044	8.3333	1.1041	0.1429	1.0286	0.2033	1.4665	0.0570	1.0838	0.0702	1.0669	0.0766	0.8076	0.0763	0.7921	0.0744	0.6590	0.0899	0.9255	0.0412	0.3363	0.7092	0.0275	0.1387	1.0688
SB590885	MZ7-mel	0.0032	uM	1	hr	8	InnoScan/Mapix	0.3378	0.1324	2.6316	0.5698	0.0475	1.0146	0.0889	0.3380	0.1284	1.5509	0.0759	1.0977	0.6135	0.8769	0.3460	0.5815	0.1186	1.6044	7.1429	1.1041	0.1698	1.0286	0.2688	1.4665	0.0497	1.0838	0.0759	1.0669	0.0943	0.8076	0.0589	0.7921	0.0633	0.6590	0.1033	0.9255	0.0430	0.3363	0.8333	0.0275	0.1786	1.0688
SB590885	MZ7-mel	0.0032	uM	5	hr	1	InnoScan/Mapix		-0.9269		-0.2283		-0.4168		-0.3845		-0.0330		-0.3952		0.0057		-0.2657		0.1322		0.2436		-0.5529		-0.2824		0.1918		-0.3392		-0.1880		-0.1263		-0.2374		-0.2614		-0.4509		-0.3369		-0.2405
SB590885	MZ7-mel	0.0032	uM	5	hr	2	InnoScan/Mapix		-0.9269		-0.2283		-0.4168		-0.3845		-0.0330		-0.3952		0.0057		-0.2657		0.1322		0.2436		-0.5529		-0.2824		0.1918		-0.3392		-0.1880		-0.1263		-0.2374		-0.2614		-0.4509		-0.3369		-0.2405
SB590885	MZ7-mel	0.0032	uM	5	hr	3	InnoScan/Mapix	0.1193	-0.9269	1.1494	-0.2283	0.0153	-0.4168	0.0482	-0.3845	0.0443	-0.0330	0.0413	-0.3952	0.3106	0.0057	0.1698	-0.2657	0.0305	0.1322	4.1667	0.2436	0.0611	-0.5529	0.0609	-0.2824	0.0327	0.1918	0.0264	-0.3392	0.0396	-0.1880	0.0459	-0.1263	0.0358	-0.2374	0.0394	-0.2614	0.0281	-0.4509	0.6579	-0.3369	0.0619	-0.2405
SB590885	MZ7-mel	0.0032	uM	5	hr	4	InnoScan/Mapix	0.1727	-0.9269	1.5385	-0.2283	0.0176	-0.4168	0.0553	-0.3845	0.0255	-0.0330	0.0261	-0.3952	0.3788	0.0057	0.2165	-0.2657	0.0676	0.1322	4.0000	0.2436	0.0532	-0.5529	0.0910	-0.2824	0.0311	0.1918	0.0347	-0.3392	0.0422	-0.1880	0.0298	-0.1263	0.0385	-0.2374	0.0432	-0.2614	0.0249	-0.4509	0.7143	-0.3369	0.0754	-0.2405
SB590885	MZ7-mel	0.0032	uM	5	hr	5	InnoScan/Mapix	0.1650	-0.9269	1.3158	-0.2283	0.0149	-0.4168	0.0418	-0.3845	0.0263	-0.0330	0.0203	-0.3952	0.2899	0.0057	0.1718	-0.2657	0.0538	0.1322	3.3333	0.2436	0.0475	-0.5529	0.1017	-0.2824	0.0226	0.1918	0.0258	-0.3392	0.0332	-0.1880	0.0383	-0.1263	0.0329	-0.2374	0.0313	-0.2614	0.0203	-0.4509	0.5848	-0.3369	0.0573	-0.2405
SB590885	MZ7-mel	0.0032	uM	5	hr	6	InnoScan/Mapix	0.1504	-0.9269	1.2195	-0.2283	0.0144	-0.4168	0.0378	-0.3845	0.0234	-0.0330	0.0200	-0.3952	0.3534	0.0057	0.1770	-0.2657	0.0430	0.1322	3.2258	0.2436	0.0479	-0.5529	0.0791	-0.2824	0.0266	0.1918	0.0280	-0.3392	0.0357	-0.1880	0.0382	-0.1263	0.0332	-0.2374	0.0355	-0.2614	0.0203	-0.4509	0.4854	-0.3369	0.0635	-0.2405
SB590885	MZ7-mel	0.0032	uM	5	hr	7	InnoScan/Mapix	0.1587	-0.9269	1.5625	-0.2283	0.0194	-0.4168	0.0621	-0.3845	0.0356	-0.0330	0.0280	-0.3952	0.3718	0.0057	0.2364	-0.2657	0.0538	0.1322	5.2632	0.2436	0.0678	-0.5529	0.0845	-0.2824	0.0333	0.1918	0.0356	-0.3392	0.0464	-0.1880	0.0344	-0.1263	0.0437	-0.2374	0.0414	-0.2614	0.0274	-0.4509	0.7299	-0.3369	0.0701	-0.2405

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HMS LINCS Project

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)