Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset - HMS LINCS Database

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)

August 25, 2015: The data file for this dataset was updated to include additional DMSO control data that were inadvertently omitted from the original version. The Assay Protocol description of how experimental data were normalized to DMSO control data also was clarified (point 9).

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Small Molecule	Cell Line	Drug Concentration	Conc Unit	Time Point	Time Point Unit	Replicate	Scanner/Software	pMEK(S217/221)	Normalized Median pMEK(S217/221)	pERK(T202/Y204)	Normalized Median pERK(T202/Y204)	p-p90RSK(S380)	Normalized Median p-p90RSK(S380)	p-p90RSK(T573)	Normalized Median p-p90RSK(T573)	p-AKT(T308)	Normalized Median p-AKT(T308)	p-AKT(S473)	Normalized Median p-AKT(S473)	p-mTOR(S2448)	Normalized Median p-mTOR(S2448)	p-p70S6K(T421/S424)	Normalized Median p-p70S6K(T421/S424)	p-p70S6K(T389)	Normalized Median p-p70S6K(T389)	p-S6(S235/236)	Normalized Median p-S6(S235/236)	p-AMPK(T172)	Normalized Median p-AMPK(T172)	p-JNK(T183/Y185)	Normalized Median p-JNK(T183/Y185)	Total c-Jun	Normalized Median Total c-Jun	p-cJun(S63)	Normalized Median p-cJun(S63)	p-P38(T180/Y182)	Normalized Median p-P38(T180/Y182)	p-HSP27(S82)	Normalized Median p-HSP27(S82)	p-NFKB(S536)	Normalized Median p-NFKB(S536)	Bim	Normalized Median Bim	cPARP	Normalized Median cPARP	p-Histone H3(S10)	Normalized Median p-Histone H3(S10)	p27 Kip1	Normalized Median p27 Kip1
	WM-115	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.0695		0.3356				0.0061		0.0082		0.0693						0.0331		0.1052		0.0198		0.0227		0.0320		0.0290		0.0162						0.0190		0.0297		0.0812		0.0126
	WM-115	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.0694		0.2916				0.0071		0.0133		0.0587						0.0319		0.0847		0.0147		0.0207		0.0318		0.0289		0.0205						0.0208		0.0330		0.0841		0.0231
	WM-115	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.0632		0.3448				0.0078		0.0140		0.0744						0.0353		0.0939		0.0194		0.0219		0.0339		0.0316		0.0167						0.0199		0.0297		0.0845		0.0187
	WM-115	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.0660		0.2985				0.0077				0.0639						0.0302		0.0786		0.0140		0.0228		0.0286		0.0269		0.0202						0.0217		0.0323		0.0831		0.0155
	WM-115	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.0622		0.3497				0.0084		0.0092		0.0751						0.0341		0.0851		0.0162		0.0222		0.0321		0.0294		0.0177						0.0206		0.0306				0.0157
	WM-115	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.0700		0.2725				0.0082		0.0084		0.0667						0.0294		0.0609		0.0122		0.0200		0.0313		0.0246		0.0131						0.0162		0.0341		0.0747		0.0163
	WM-115	0.0000	uM	48	hr	7	Odyssey/Microvigene	0.0639		0.3413						0.0094		0.0861						0.0352		0.0728		0.0165		0.0218		0.0336		0.0259		0.0139						0.0189		0.0358		0.0732		0.0180
	WM-115	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.0724		0.2941						0.0109		0.0560						0.0306		0.0704		0.0160		0.0185		0.0331		0.0279		0.0162						0.0209		0.0324		0.0763		0.0159
	WM-115	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.0647		0.3086				0.0087		0.0088		0.0769						0.0334		0.0766		0.0150		0.0215		0.0356		0.0278		0.0156						0.0166		0.0315		0.0955		0.0174
	WM-115	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.0623		0.2577				0.0076		0.0108		0.0657						0.0309		0.0787		0.0135		0.0187		0.0345		0.0281		0.0138						0.0184		0.0320		0.0893		0.0164
	WM-115	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.0566		0.3086				0.0093		0.0117		0.0844						0.0401		0.0844		0.0182		0.0202		0.0353		0.0297		0.0154						0.0187		0.0331		0.0885		0.0184
	WM-115	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.0567		0.3021				0.0078		0.0085		0.0566						0.0290		0.0769				0.0209				0.0337		0.0137						0.0222		0.0279		0.0715		0.0165
	WM-115	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.0550		0.3497				0.0094		0.0099		0.0776						0.0360		0.0803		0.0190		0.0221		0.0331		0.0349		0.0172						0.0194		0.0286		0.0872		0.0197
	WM-115	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.0612		0.2778				0.0092		0.0090		0.0677						0.0333		0.0835		0.0137		0.0200		0.0339		0.0284		0.0181						0.0167		0.0319		0.0913		0.0182
	WM-115	0.0000	uM	48	hr	8	Odyssey/Microvigene	0.0583		0.3378				0.0109		0.0091		0.0876						0.0402		0.0873		0.0196		0.0222		0.0361		0.0345		0.0161						0.0192		0.0330		0.0986		0.0201
SB590885	WM1552C	0.0032	uM	1	hr	1	InnoScan/Mapix	0.0405	0.6862	0.8696	1.2895	0.0908	1.0099	0.0451	0.7709	0.0197	1.1965	0.0261	1.5779	0.0097	1.3016	0.0152	1.4760	0.0158	1.3511	0.0344	0.2373	0.0979	1.4147	0.0576	1.1874	0.1862	1.2412	0.0362	1.0482	0.0151	1.3078	0.0122	0.9089	0.0148	0.9536	0.0282	1.6350	0.0124	1.1072	0.0712	-0.2672	0.1151	1.0351
SB590885	WM1552C	0.0032	uM	1	hr	2	InnoScan/Mapix	0.0478	0.6862		1.2895	0.1062	1.0099	0.0536	0.7709	0.0186	1.1965	0.0316	1.5779	0.0119	1.3016	0.0168	1.4760	0.0162	1.3511	0.0388	0.2373	0.1304	1.4147	0.0665	1.1874	0.2841	1.2412	0.0319	1.0482	0.0153	1.3078	0.0093	0.9089	0.0139	0.9536	0.0339	1.6350	0.0151	1.1072		-0.2672	0.1647	1.0351
SB590885	WM1552C	0.0032	uM	1	hr	3	InnoScan/Mapix	0.0541	0.6862	0.6897	1.2895	0.1199	1.0099	0.0542	0.7709	0.0313	1.1965	0.0236	1.5779	0.0120	1.3016	0.0211	1.4760	0.0246	1.3511	0.0412	0.2373	0.0958	1.4147	0.0608	1.1874	0.1664	1.2412	0.0417	1.0482		1.3078	0.0142	0.9089	0.0209	0.9536		1.6350	0.0161	1.1072	0.0537	-0.2672	0.1377	1.0351
SB590885	WM1552C	0.0032	uM	1	hr	4	InnoScan/Mapix	0.0399	0.6862	0.8547	1.2895	0.1043	1.0099	0.0416	0.7709	0.0323	1.1965	0.0259	1.5779	0.0115	1.3016	0.0157	1.4760	0.0154	1.3511	0.0325	0.2373	0.1036	1.4147	0.0582	1.1874	0.1842	1.2412	0.0317	1.0482	0.0167	1.3078	0.0091	0.9089	0.0139	0.9536	0.0313	1.6350	0.0148	1.1072	0.0641	-0.2672	0.1135	1.0351
SB590885	WM1552C	0.0032	uM	1	hr	5	InnoScan/Mapix	0.0429	0.6862	0.7407	1.2895	0.0879	1.0099	0.0450	0.7709	0.0202	1.1965	0.0302	1.5779	0.0106	1.3016	0.0146	1.4760	0.0151	1.3511	0.0411	0.2373	0.1482	1.4147	0.0619	1.1874	0.1825	1.2412	0.0410	1.0482	0.0154	1.3078	0.0119	0.9089	0.0137	0.9536	0.0246	1.6350	0.0128	1.1072	0.0577	-0.2672	0.1341	1.0351
SB590885	WM1552C	0.0032	uM	1	hr	6	InnoScan/Mapix	0.0499	0.6862	0.9259	1.2895	0.1227	1.0099	0.0684	0.7709	0.0202	1.1965	0.0395	1.5779	0.0118	1.3016	0.0203	1.4760	0.0204	1.3511	0.0451	0.2373	0.2075	1.4147	0.0745	1.1874	0.2762	1.2412	0.0359	1.0482	0.0138	1.3078	0.0094	0.9089		0.9536	0.0378	1.6350	0.0101	1.1072	0.0670	-0.2672	0.1876	1.0351
SB590885	WM1552C	0.0032	uM	1	hr	7	InnoScan/Mapix	0.0498	0.6862	0.6536	1.2895	0.1064	1.0099	0.0433	0.7709	0.0214	1.1965	0.0240	1.5779	0.0098	1.3016	0.0199	1.4760	0.0212	1.3511	0.0395	0.2373	0.1370	1.4147	0.0635	1.1874	0.1653	1.2412	0.0352	1.0482	0.0173	1.3078	0.0122	0.9089	0.0180	0.9536	0.0405	1.6350		1.1072	0.0570	-0.2672	0.1238	1.0351
SB590885	WM1552C	0.0032	uM	1	hr	8	InnoScan/Mapix	0.0442	0.6862	0.7353	1.2895	0.0974	1.0099	0.0448	0.7709	0.0258	1.1965	0.0306	1.5779	0.0082	1.3016	0.0153	1.4760	0.0152	1.3511	0.0382	0.2373	0.1546	1.4147	0.0578	1.1874	0.2326	1.2412	0.0309	1.0482	0.0173	1.3078	0.0086	0.9089	0.0131	0.9536	0.0308	1.6350	0.0143	1.1072	0.0629	-0.2672	0.1124	1.0351
SB590885	WM1552C	0.0032	uM	5	hr	1	InnoScan/Mapix	0.0291	-0.0616	0.3690	0.1399	0.0559	0.0966	0.0381	0.4953	0.0093	0.0781	0.0082	-0.4121	0.0063	0.2095	0.0061	0.0590	0.0063	-0.0305	0.0132	-0.7401	0.0533	0.1910	0.0322	0.0956	0.1040	0.3222	0.0312	0.5353	0.0063	-0.0661	0.0097	0.5776	0.0092	-0.0935	0.0155	0.2441	0.0060	-0.1941	0.0629	-0.5662	0.0734	0.1871
SB590885	WM1552C	0.0032	uM	5	hr	2	InnoScan/Mapix	0.0324	-0.0616	0.5155	0.1399	0.0705	0.0966	0.0485	0.4953	0.0086	0.0781	0.0091	-0.4121	0.0060	0.2095	0.0071	0.0590	0.0065	-0.0305	0.0153	-0.7401	0.0698	0.1910	0.0365	0.0956	0.1553	0.3222	0.0314	0.5353	0.0052	-0.0661	0.0120	0.5776	0.0064	-0.0935	0.0144	0.2441	0.0062	-0.1941	0.0739	-0.5662	0.0969	0.1871

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HMS LINCS Project

Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)