Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | WM-115 | 1.0000 | uM | 24 | hr | 386 | 42 | 0.6570 | 0.8900 | 0.1088 | 0.1020 | 2 |
| Selumetinib | WM-115 | 1.0000 | uM | 24 | hr | 639 | 58 | 1.1096 | 0.8900 | 0.0908 | 0.1020 | 3 |
| Selumetinib | WM-115 | 1.0000 | uM | 24 | hr | 564 | 64 | 0.9549 | 0.8900 | 0.1135 | 0.1020 | 4 |
| Selumetinib | WM-115 | 1.0000 | uM | 48 | hr | 501 | 85 | 0.8399 | 0.8227 | 0.1697 | 0.1858 | 1 |
| Selumetinib | WM-115 | 1.0000 | uM | 48 | hr | 508 | 98 | 0.8277 | 0.8227 | 0.1929 | 0.1858 | 2 |
| Selumetinib | WM-115 | 1.0000 | uM | 48 | hr | 510 | 96 | 0.8358 | 0.8227 | 0.1882 | 0.1858 | 3 |
| Selumetinib | WM-115 | 1.0000 | uM | 48 | hr | 483 | 93 | 0.7874 | 0.8227 | 0.1926 | 0.1858 | 4 |
| Selumetinib | WM-115 | 1.0000 | uM | 72 | hr | 1778 | 642 | 0.3747 | 0.4086 | 0.3611 | 0.3021 | 1 |
| Selumetinib | WM-115 | 1.0000 | uM | 72 | hr | 1782 | 557 | 0.4041 | 0.4086 | 0.3126 | 0.3021 | 2 |
| Selumetinib | WM-115 | 1.0000 | uM | 72 | hr | 1691 | 446 | 0.4107 | 0.4086 | 0.2638 | 0.3021 | 3 |
| Selumetinib | WM-115 | 1.0000 | uM | 72 | hr | 1850 | 501 | 0.4450 | 0.4086 | 0.2708 | 0.3021 | 4 |
| Selumetinib | WM-115 | 3.1600 | uM | 24 | hr | 378 | 71 | 0.5863 | 0.7277 | 0.1878 | 0.1433 | 1 |
| Selumetinib | WM-115 | 3.1600 | uM | 24 | hr | 347 | 46 | 0.5749 | 0.7277 | 0.1326 | 0.1433 | 2 |
| Selumetinib | WM-115 | 3.1600 | uM | 24 | hr | 432 | 62 | 0.7067 | 0.7277 | 0.1435 | 0.1433 | 3 |
| Selumetinib | WM-115 | 3.1600 | uM | 24 | hr | 613 | 67 | 1.0428 | 0.7277 | 0.1093 | 0.1433 | 4 |
| Selumetinib | WM-115 | 3.1600 | uM | 48 | hr | 410 | 123 | 0.5794 | 0.5920 | 0.3000 | 0.2687 | 1 |
| Selumetinib | WM-115 | 3.1600 | uM | 48 | hr | 469 | 115 | 0.7147 | 0.5920 | 0.2452 | 0.2687 | 2 |
| Selumetinib | WM-115 | 3.1600 | uM | 48 | hr | 395 | 90 | 0.6158 | 0.5920 | 0.2279 | 0.2687 | 3 |
| Selumetinib | WM-115 | 3.1600 | uM | 48 | hr | 325 | 98 | 0.4583 | 0.5920 | 0.3015 | 0.2687 | 4 |
| Selumetinib | WM-115 | 3.1600 | uM | 72 | hr | 1468 | 737 | 0.2411 | 0.2872 | 0.5020 | 0.4564 | 1 |
| Selumetinib | WM-115 | 3.1600 | uM | 72 | hr | 1509 | 630 | 0.2900 | 0.2872 | 0.4175 | 0.4564 | 2 |
| Selumetinib | WM-115 | 3.1600 | uM | 72 | hr | 1708 | 820 | 0.2929 | 0.2872 | 0.4801 | 0.4564 | 3 |
| Selumetinib | WM-115 | 3.1600 | uM | 72 | hr | 1714 | 730 | 0.3246 | 0.2872 | 0.4259 | 0.4564 | 4 |
| Vemurafenib | WM-115 | 0.0032 | uM | 24 | hr | 643 | 38 | 1.1555 | 1.1746 | 0.0591 | 0.0555 | 1 |
| Vemurafenib | WM-115 | 0.0032 | uM | 24 | hr | 680 | 25 | 1.2510 | 1.1746 | 0.0368 | 0.0555 | 2 |