Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | MCF 10A | 0 (control) | 24 | hr | 392.51 | 146.93 | p-S6 | 372.04 | | |
| Torkinib | MCF 10A | 0 (control) | 6 | hr | 492.19 | 171.34 | p-S6 | 630.46 | | |
| Torkinib | MCF 10A | 0 (control) | 24 | hr | 414.87 | 143.54 | p-S6 | 344.96 | | |
| GSK1059615 | MCF 10A | 0 (control) | 6 | hr | 464.90 | 176.96 | p-S6 | 659.82 | | |
| GSK1059615 | MCF 10A | 0 (control) | 24 | hr | 452.11 | 153.53 | p-S6 | 374.41 | | |
| MK2206 | MCF 10A | 0 (control) | 6 | hr | 449.92 | 155.83 | p-S6 | 579.06 | | |
| MK2206 | MCF 10A | 0 (control) | 24 | hr | 386.87 | 142.11 | p-S6 | 317.85 | | |
| Triciribine | MCF 10A | 0 (control) | 6 | hr | 451.65 | 156.02 | p-S6 | 578.30 | | |
| Triciribine | MCF 10A | 0 (control) | 24 | hr | 372.23 | 128.54 | p-S6 | 303.05 | | |
| Dactolisib | MCF 10A | 0 (control) | 6 | hr | 437.21 | 161.21 | p-S6 | 640.43 | | |
| Dactolisib | MCF 10A | 0 (control) | 24 | hr | 369.10 | 128.85 | p-S6 | 315.93 | | |
| Gefitinib | T47D | 0 (control) | 6 | hr | 203.26 | 107.16 | p-S6 | 473.67 | | |
| Gefitinib | T47D | 0 (control) | 24 | hr | 162.41 | 108.98 | p-S6 | 350.93 | | |
| Torkinib | T47D | 0 (control) | 6 | hr | 165.21 | 93.01 | p-S6 | 494.26 | | |
| Torkinib | T47D | 0 (control) | 24 | hr | 158.20 | 100.14 | p-S6 | 339.64 | | |
| GSK1059615 | T47D | 0 (control) | 6 | hr | 159.41 | 93.11 | p-S6 | 486.19 | | |
| GSK1059615 | T47D | 0 (control) | 24 | hr | 165.98 | 94.02 | p-S6 | 345.47 | | |
| MK2206 | T47D | 0 (control) | 6 | hr | 91.40 | 33.14 | p-S6 | 37.61 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 163.84 | 97.22 | p-S6 | 365.93 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 100.63 | 39.21 | p-S6 | 42.73 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 154.46 | 91.62 | p-S6 | 375.48 | | |
| Dactolisib | T47D | 0 (control) | 6 | hr | 89.64 | 29.16 | p-S6 | 44.67 | | |
| Dactolisib | T47D | 0 (control) | 24 | hr | 133.02 | 96.95 | p-S6 | 277.57 | | |
| Gefitinib | AU565 | 1.0 | nM | 6 | hr | 269.00 | 60.51 | p-S6 | 148.29 | |
| Gefitinib | AU565 | 1.0 | nM | 24 | hr | 559.78 | 127.56 | p-S6 | 500.36 | |