Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | AU565 | 0 (control) | 6 | hr | 230.66 | 50.40 | p-S6 | 113.96 | | |
| Gefitinib | AU565 | 0 (control) | 24 | hr | 565.94 | 130.77 | p-S6 | 519.83 | | |
| Torkinib | AU565 | 0 (control) | 6 | hr | 211.09 | 48.63 | p-S6 | 116.79 | | |
| Torkinib | AU565 | 0 (control) | 24 | hr | 465.18 | 117.67 | p-S6 | 506.95 | | |
| GSK1059615 | AU565 | 0 (control) | 6 | hr | 198.05 | 47.32 | p-S6 | 107.77 | | |
| GSK1059615 | AU565 | 0 (control) | 24 | hr | 399.90 | 111.13 | p-S6 | 491.88 | | |
| MK2206 | AU565 | 0 (control) | 6 | hr | 202.91 | 61.14 | p-S6 | 108.44 | | |
| MK2206 | AU565 | 0 (control) | 24 | hr | 408.07 | 126.50 | p-S6 | 523.81 | | |
| Triciribine | AU565 | 0 (control) | 6 | hr | 245.35 | 63.92 | p-S6 | 130.83 | | |
| Triciribine | AU565 | 0 (control) | 24 | hr | 458.45 | 120.14 | p-S6 | 500.89 | | |
| Dactolisib | AU565 | 0 (control) | 6 | hr | 215.43 | 52.44 | p-S6 | 139.71 | | |
| Dactolisib | AU565 | 0 (control) | 24 | hr | 490.41 | 118.84 | p-S6 | 476.50 | | |
| Gefitinib | HCC1954 | 0 (control) | 6 | hr | 391.89 | 87.17 | p-S6 | 289.58 | | |
| Gefitinib | HCC1954 | 0 (control) | 24 | hr | 321.97 | 119.75 | p-S6 | 344.58 | | |
| Torkinib | HCC1954 | 0 (control) | 6 | hr | 182.11 | 41.43 | p-S6 | 89.40 | | |
| Torkinib | HCC1954 | 0 (control) | 24 | hr | 312.09 | 109.93 | p-S6 | 406.83 | | |
| GSK1059615 | HCC1954 | 0 (control) | 6 | hr | 284.95 | 80.93 | p-S6 | 207.09 | | |
| GSK1059615 | HCC1954 | 0 (control) | 24 | hr | 293.66 | 109.21 | p-S6 | 287.91 | | |
| MK2206 | HCC1954 | 0 (control) | 6 | hr | 311.89 | 86.20 | p-S6 | 351.16 | | |
| MK2206 | HCC1954 | 0 (control) | 24 | hr | 304.79 | 113.56 | p-S6 | 312.78 | | |
| Triciribine | HCC1954 | 0 (control) | 6 | hr | 242.63 | 86.72 | p-S6 | 308.51 | | |
| Triciribine | HCC1954 | 0 (control) | 24 | hr | 306.90 | 103.89 | p-S6 | 336.39 | | |
| Dactolisib | HCC1954 | 0 (control) | 6 | hr | 184.34 | 66.18 | p-S6 | 158.93 | | |
| Dactolisib | HCC1954 | 0 (control) | 24 | hr | 272.84 | 109.74 | p-S6 | 335.45 | | |
| Gefitinib | MCF 10A | 0 (control) | 6 | hr | 428.74 | 166.98 | p-S6 | 510.09 | |