Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | MCF 10A | 100.0 | nM | 24 | hr | 406.38 | 94.90 | p-S6 | 314.65 | |
| Gefitinib | T47D | 100.0 | nM | 6 | hr | 165.55 | 103.85 | p-S6 | 465.61 | |
| Gefitinib | T47D | 100.0 | nM | 24 | hr | 143.69 | 107.66 | p-S6 | 331.64 | |
| Torkinib | T47D | 31.6 | nM | 6 | hr | 164.67 | 91.99 | p-S6 | 27.52 | |
| Torkinib | T47D | 31.6 | nM | 24 | hr | 132.90 | 53.60 | p-S6 | 13.00 | |
| GSK1059615 | T47D | 100.0 | nM | 6 | hr | 164.04 | 98.99 | p-S6 | 454.45 | |
| GSK1059615 | T47D | 100.0 | nM | 24 | hr | 136.59 | 92.08 | p-S6 | 280.44 | |
| MK2206 | T47D | 100.0 | nM | 6 | hr | 97.67 | 36.57 | p-S6 | 34.89 | |
| MK2206 | T47D | 100.0 | nM | 24 | hr | 129.23 | 87.88 | p-S6 | 388.78 | |
| Triciribine | T47D | 100.0 | nM | 6 | hr | 100.14 | 39.93 | p-S6 | 51.70 | |
| Triciribine | T47D | 100.0 | nM | 24 | hr | 164.58 | 84.80 | p-S6 | 393.63 | |
| Dactolisib | T47D | 100.0 | nM | 6 | hr | 90.18 | 40.47 | p-S6 | 4.14 | |
| Dactolisib | T47D | 100.0 | nM | 24 | hr | 106.94 | 39.36 | p-S6 | 5.92 | |
| Gefitinib | AU565 | 316.0 | nM | 6 | hr | 229.96 | 58.85 | p-S6 | 64.24 | |
| Gefitinib | AU565 | 316.0 | nM | 24 | hr | 422.43 | 94.36 | p-S6 | 441.87 | |
| Torkinib | AU565 | 133.0 | nM | 6 | hr | 419.51 | 67.57 | p-S6 | 21.02 | |
| Torkinib | AU565 | 133.0 | nM | 24 | hr | 362.94 | 59.08 | p-S6 | 10.45 | |
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 235.34 | 52.98 | p-S6 | 29.06 | |
| GSK1059615 | AU565 | 316.0 | nM | 24 | hr | 494.00 | 84.06 | p-S6 | 167.01 | |
| MK2206 | AU565 | 316.0 | nM | 6 | hr | 416.27 | 84.19 | p-S6 | 167.32 | |
| MK2206 | AU565 | 316.0 | nM | 24 | hr | 368.36 | 83.55 | p-S6 | 175.01 | |
| Triciribine | AU565 | 316.0 | nM | 6 | hr | 267.44 | 64.67 | p-S6 | 101.29 | |
| Triciribine | AU565 | 316.0 | nM | 24 | hr | 526.01 | 101.29 | p-S6 | 302.92 | |
| Dactolisib | AU565 | 316.0 | nM | 6 | hr | 268.71 | 58.81 | p-S6 | 13.22 | |
| Dactolisib | AU565 | 316.0 | nM | 24 | hr | 436.33 | 59.46 | p-S6 | 12.66 | |