Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | HCC1954 | 316.0 | nM | 6 | hr | 199.95 | 83.42 | p-S6 | 224.21 | |
| Gefitinib | HCC1954 | 316.0 | nM | 24 | hr | 260.22 | 110.87 | p-S6 | 320.57 | |
| Torkinib | HCC1954 | 133.0 | nM | 6 | hr | 217.10 | 56.50 | p-S6 | 14.26 | |
| Torkinib | HCC1954 | 133.0 | nM | 24 | hr | 359.28 | 105.35 | p-S6 | 58.87 | |
| GSK1059615 | HCC1954 | 316.0 | nM | 6 | hr | 364.49 | 73.45 | p-S6 | 28.32 | |
| GSK1059615 | HCC1954 | 316.0 | nM | 24 | hr | 270.39 | 70.25 | p-S6 | 13.40 | |
| MK2206 | HCC1954 | 316.0 | nM | 6 | hr | 260.65 | 75.82 | p-S6 | 262.28 | |
| MK2206 | HCC1954 | 316.0 | nM | 24 | hr | 258.30 | 107.75 | p-S6 | 322.39 | |
| Triciribine | HCC1954 | 316.0 | nM | 6 | hr | 230.80 | 81.11 | p-S6 | 306.72 | |
| Triciribine | HCC1954 | 316.0 | nM | 24 | hr | 252.81 | 105.06 | p-S6 | 356.88 | |
| Dactolisib | HCC1954 | 316.0 | nM | 6 | hr | 195.79 | 64.22 | p-S6 | 10.13 | |
| Dactolisib | HCC1954 | 316.0 | nM | 24 | hr | 271.83 | 70.38 | p-S6 | 15.10 | |
| Gefitinib | MCF 10A | 316.0 | nM | 6 | hr | 216.22 | 164.48 | p-S6 | 482.58 | |
| Gefitinib | MCF 10A | 316.0 | nM | 24 | hr | 296.12 | 182.11 | p-S6 | 712.92 | |
| Torkinib | MCF 10A | 133.0 | nM | 6 | hr | 548.44 | 168.01 | p-S6 | 609.66 | |
| Torkinib | MCF 10A | 133.0 | nM | 24 | hr | 530.52 | 155.64 | p-S6 | 629.03 | |
| GSK1059615 | MCF 10A | 316.0 | nM | 6 | hr | 287.56 | 170.76 | p-S6 | 334.44 | |
| GSK1059615 | MCF 10A | 316.0 | nM | 24 | hr | 374.56 | 163.40 | p-S6 | 296.09 | |
| MK2206 | MCF 10A | 316.0 | nM | 6 | hr | 346.22 | 157.32 | p-S6 | 537.09 | |
| MK2206 | MCF 10A | 316.0 | nM | 24 | hr | 296.51 | 154.41 | p-S6 | 304.75 | |
| Triciribine | MCF 10A | 316.0 | nM | 6 | hr | 347.05 | 158.30 | p-S6 | 541.94 | |
| Triciribine | MCF 10A | 316.0 | nM | 24 | hr | 297.79 | 145.81 | p-S6 | 300.11 | |
| Dactolisib | MCF 10A | 316.0 | nM | 6 | hr | 356.11 | 121.07 | p-S6 | 341.72 | |
| Dactolisib | MCF 10A | 316.0 | nM | 24 | hr | 385.31 | 52.88 | p-S6 | 244.55 | |
| Gefitinib | T47D | 316.0 | nM | 6 | hr | 156.57 | 100.00 | p-S6 | 465.07 | |