HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
MK2206	T47D	1.0	nM	6	hr	113.20	60.58	p-S6	77.86
MK2206	T47D	1.0	nM	24	hr	161.93	107.32	p-S6	357.52
Triciribine	T47D	1.0	nM	6	hr	99.04	48.18	p-S6	56.59
Triciribine	T47D	1.0	nM	24	hr	152.97	102.07	p-S6	357.04
Dactolisib	T47D	1.0	nM	6	hr	102.89	57.24	p-S6	73.06
Dactolisib	T47D	1.0	nM	24	hr	140.57	100.31	p-S6	315.62
Gefitinib	AU565	3.16	nM	6	hr	268.55	59.48	p-S6	131.60
Gefitinib	AU565	3.16	nM	24	hr	571.55	130.70	p-S6	558.33
Torkinib	AU565	0.422	nM	6	hr	297.99	64.59	p-S6	137.32
Torkinib	AU565	0.422	nM	24	hr	486.10	119.56	p-S6	478.18
GSK1059615	AU565	3.16	nM	6	hr	407.79	90.85	p-S6	287.44
GSK1059615	AU565	3.16	nM	24	hr	451.76	117.41	p-S6	545.16
MK2206	AU565	3.16	nM	6	hr	368.31	89.82	p-S6	319.52
MK2206	AU565	3.16	nM	24	hr	418.20	129.03	p-S6	540.93
Triciribine	AU565	3.16	nM	6	hr	407.81	100.49	p-S6	379.52
Triciribine	AU565	3.16	nM	24	hr	537.40	126.81	p-S6	494.49
Dactolisib	AU565	3.16	nM	6	hr	217.68	50.97	p-S6	71.68
Dactolisib	AU565	3.16	nM	24	hr	509.48	113.22	p-S6	302.11
Gefitinib	HCC1954	3.16	nM	6	hr	312.21	67.17	p-S6	132.68
Gefitinib	HCC1954	3.16	nM	24	hr	284.62	118.60	p-S6	273.05
Torkinib	HCC1954	0.422	nM	6	hr	204.28	49.24	p-S6	118.41
Torkinib	HCC1954	0.422	nM	24	hr	288.79	112.90	p-S6	376.36
GSK1059615	HCC1954	3.16	nM	6	hr	461.88	105.26	p-S6	452.98
GSK1059615	HCC1954	3.16	nM	24	hr	296.42	109.09	p-S6	296.49
MK2206	HCC1954	3.16	nM	6	hr	220.45	69.34	p-S6	157.77

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