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Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
MK2206	HCC1954	3.16	nM	24	hr	291.56	114.70	p-S6	313.12
Triciribine	HCC1954	3.16	nM	6	hr	275.93	96.79	p-S6	400.96
Triciribine	HCC1954	3.16	nM	24	hr	320.01	105.29	p-S6	296.94
Dactolisib	HCC1954	3.16	nM	6	hr	197.54	49.32	p-S6	74.13
Dactolisib	HCC1954	3.16	nM	24	hr	322.53	129.16	p-S6	398.32
Gefitinib	MCF 10A	3.16	nM	6	hr	412.15	167.05	p-S6	473.00
Gefitinib	MCF 10A	3.16	nM	24	hr	378.41	167.92	p-S6	404.02
Torkinib	MCF 10A	0.422	nM	6	hr	430.95	160.56	p-S6	549.49
Torkinib	MCF 10A	0.422	nM	24	hr	401.13	169.08	p-S6	399.89
GSK1059615	MCF 10A	3.16	nM	6	hr	400.80	171.47	p-S6	490.69
GSK1059615	MCF 10A	3.16	nM	24	hr	355.33	150.64	p-S6	389.13
MK2206	MCF 10A	3.16	nM	6	hr	382.68	160.22	p-S6	463.46
MK2206	MCF 10A	3.16	nM	24	hr	295.88	148.69	p-S6	275.10
Triciribine	MCF 10A	3.16	nM	6	hr	384.87	160.63	p-S6	464.60
Triciribine	MCF 10A	3.16	nM	24	hr	267.46	146.10	p-S6	248.42
Dactolisib	MCF 10A	3.16	nM	6	hr	363.20	160.88	p-S6	495.27
Dactolisib	MCF 10A	3.16	nM	24	hr	251.44	143.62	p-S6	228.95
Gefitinib	T47D	3.16	nM	6	hr	191.33	107.09	p-S6	441.08
Gefitinib	T47D	3.16	nM	24	hr	165.53	122.53	p-S6	338.85
Torkinib	T47D	0.422	nM	6	hr	188.74	98.75	p-S6	471.80
Torkinib	T47D	0.422	nM	24	hr	171.91	116.89	p-S6	335.63
GSK1059615	T47D	3.16	nM	6	hr	180.28	98.22	p-S6	470.54
GSK1059615	T47D	3.16	nM	24	hr	165.28	107.90	p-S6	347.25
MK2206	T47D	3.16	nM	6	hr	100.59	50.08	p-S6	61.09
MK2206	T47D	3.16	nM	24	hr	158.13	105.42	p-S6	367.37

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