Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | HCC1954 | 1.0 | nM | 24 | hr | 304.58 | 106.36 | p-S6 | 320.25 | |
| MK2206 | HCC1954 | 1.0 | nM | 6 | hr | 203.48 | 69.98 | p-S6 | 150.86 | |
| MK2206 | HCC1954 | 1.0 | nM | 24 | hr | 293.92 | 113.37 | p-S6 | 303.58 | |
| Triciribine | HCC1954 | 1.0 | nM | 6 | hr | 273.39 | 95.53 | p-S6 | 432.10 | |
| Triciribine | HCC1954 | 1.0 | nM | 24 | hr | 307.85 | 106.82 | p-S6 | 305.43 | |
| Dactolisib | HCC1954 | 1.0 | nM | 6 | hr | 221.39 | 85.08 | p-S6 | 226.60 | |
| Dactolisib | HCC1954 | 1.0 | nM | 24 | hr | 297.75 | 117.19 | p-S6 | 355.47 | |
| Gefitinib | MCF 10A | 1.0 | nM | 6 | hr | 424.19 | 165.67 | p-S6 | 452.39 | |
| Gefitinib | MCF 10A | 1.0 | nM | 24 | hr | 355.52 | 156.59 | p-S6 | 408.54 | |
| Torkinib | MCF 10A | 0.1 | nM | 6 | hr | 476.60 | 159.54 | p-S6 | 503.96 | |
| Torkinib | MCF 10A | 0.1 | nM | 24 | hr | 422.39 | 160.17 | p-S6 | 363.48 | |
| GSK1059615 | MCF 10A | 1.0 | nM | 6 | hr | 425.87 | 164.93 | p-S6 | 468.28 | |
| GSK1059615 | MCF 10A | 1.0 | nM | 24 | hr | 368.24 | 149.02 | p-S6 | 349.59 | |
| MK2206 | MCF 10A | 1.0 | nM | 6 | hr | 400.04 | 156.74 | p-S6 | 410.91 | |
| MK2206 | MCF 10A | 1.0 | nM | 24 | hr | 309.43 | 140.57 | p-S6 | 255.16 | |
| Triciribine | MCF 10A | 1.0 | nM | 6 | hr | 401.41 | 156.95 | p-S6 | 411.77 | |
| Triciribine | MCF 10A | 1.0 | nM | 24 | hr | 292.56 | 133.91 | p-S6 | 259.07 | |
| Dactolisib | MCF 10A | 1.0 | nM | 6 | hr | 372.36 | 161.22 | p-S6 | 492.63 | |
| Dactolisib | MCF 10A | 1.0 | nM | 24 | hr | 267.58 | 131.31 | p-S6 | 223.40 | |
| Gefitinib | T47D | 1.0 | nM | 6 | hr | 199.89 | 107.14 | p-S6 | 443.29 | |
| Gefitinib | T47D | 1.0 | nM | 24 | hr | 185.57 | 117.36 | p-S6 | 338.95 | |
| Torkinib | T47D | 0.1 | nM | 6 | hr | 188.44 | 98.08 | p-S6 | 463.83 | |
| Torkinib | T47D | 0.1 | nM | 24 | hr | 174.57 | 117.83 | p-S6 | 340.26 | |
| GSK1059615 | T47D | 1.0 | nM | 6 | hr | 169.47 | 94.04 | p-S6 | 455.83 | |
| GSK1059615 | T47D | 1.0 | nM | 24 | hr | 159.11 | 101.40 | p-S6 | 338.36 | |