Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Dactolisib | AU565 | 3.16 | uM | 24 | hr | 470.31 | 69.46 | p-4EBP1 | 9.61 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 140.11 | 52.98 | p-4EBP1 | 71.75 | |
| Gefitinib | HCC1954 | 3.16 | uM | 24 | hr | 246.05 | 85.18 | p-4EBP1 | 127.57 | |
| Torkinib | HCC1954 | 2.37 | uM | 6 | hr | 175.04 | 34.08 | p-4EBP1 | 7.70 | |
| Torkinib | HCC1954 | 2.37 | uM | 24 | hr | 259.94 | 73.76 | p-4EBP1 | 14.08 | |
| GSK1059615 | HCC1954 | 3.16 | uM | 6 | hr | 338.67 | 67.32 | p-4EBP1 | 16.70 | |
| GSK1059615 | HCC1954 | 3.16 | uM | 24 | hr | 293.10 | 64.56 | p-4EBP1 | 16.43 | |
| MK2206 | HCC1954 | 3.16 | uM | 6 | hr | 262.02 | 73.42 | p-4EBP1 | 97.37 | |
| MK2206 | HCC1954 | 3.16 | uM | 24 | hr | 276.15 | 85.56 | p-4EBP1 | 107.23 | |
| Triciribine | HCC1954 | 3.16 | uM | 6 | hr | 261.16 | 86.81 | p-4EBP1 | 126.98 | |
| Triciribine | HCC1954 | 3.16 | uM | 24 | hr | 251.30 | 102.03 | p-4EBP1 | 110.33 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 233.33 | 68.76 | p-4EBP1 | 8.74 | |
| Dactolisib | HCC1954 | 3.16 | uM | 24 | hr | 243.66 | 67.52 | p-4EBP1 | 10.70 | |
| Gefitinib | MCF 10A | 3.16 | uM | 6 | hr | 183.33 | 133.02 | p-4EBP1 | 284.87 | |
| Gefitinib | MCF 10A | 3.16 | uM | 24 | hr | 178.06 | 28.30 | p-4EBP1 | 142.46 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 612.51 | 140.42 | p-4EBP1 | 13.01 | |
| Torkinib | MCF 10A | 2.37 | uM | 24 | hr | 440.66 | 66.81 | p-4EBP1 | 16.14 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 6 | hr | 201.71 | 115.99 | p-4EBP1 | 24.75 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 24 | hr | 206.97 | 114.82 | p-4EBP1 | 17.75 | |
| MK2206 | MCF 10A | 3.16 | uM | 6 | hr | 359.04 | 139.23 | p-4EBP1 | 338.01 | |
| MK2206 | MCF 10A | 3.16 | uM | 24 | hr | 337.52 | 165.13 | p-4EBP1 | 185.49 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 360.15 | 139.85 | p-4EBP1 | 338.46 | |
| Triciribine | MCF 10A | 3.16 | uM | 24 | hr | 296.35 | 132.49 | p-4EBP1 | 192.33 | |
| Dactolisib | MCF 10A | 3.16 | uM | 6 | hr | 283.91 | 122.02 | p-4EBP1 | 6.68 | |
| Dactolisib | MCF 10A | 3.16 | uM | 24 | hr | 332.47 | 73.29 | p-4EBP1 | 11.86 | |