Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | HCC1954 | 10.0 | nM | 24 | hr | 311.23 | 108.19 | p-S6 | 304.64 | |
| Dactolisib | HCC1954 | 10.0 | nM | 6 | hr | 162.93 | 43.47 | p-S6 | 11.98 | |
| Dactolisib | HCC1954 | 10.0 | nM | 24 | hr | 334.72 | 100.93 | p-S6 | 32.09 | |
| Gefitinib | MCF 10A | 10.0 | nM | 6 | hr | 395.94 | 174.01 | p-S6 | 463.91 | |
| Gefitinib | MCF 10A | 10.0 | nM | 24 | hr | 371.59 | 183.06 | p-S6 | 412.89 | |
| Torkinib | MCF 10A | 1.78 | nM | 6 | hr | 478.51 | 162.83 | p-S6 | 559.27 | |
| Torkinib | MCF 10A | 1.78 | nM | 24 | hr | 422.24 | 174.63 | p-S6 | 410.26 | |
| GSK1059615 | MCF 10A | 10.0 | nM | 6 | hr | 417.46 | 174.01 | p-S6 | 501.03 | |
| GSK1059615 | MCF 10A | 10.0 | nM | 24 | hr | 340.07 | 149.51 | p-S6 | 365.03 | |
| MK2206 | MCF 10A | 10.0 | nM | 6 | hr | 390.73 | 154.71 | p-S6 | 437.85 | |
| MK2206 | MCF 10A | 10.0 | nM | 24 | hr | 306.08 | 141.79 | p-S6 | 251.95 | |
| Triciribine | MCF 10A | 10.0 | nM | 6 | hr | 393.14 | 155.67 | p-S6 | 439.99 | |
| Triciribine | MCF 10A | 10.0 | nM | 24 | hr | 249.75 | 142.62 | p-S6 | 229.91 | |
| Dactolisib | MCF 10A | 10.0 | nM | 6 | hr | 353.43 | 156.34 | p-S6 | 500.28 | |
| Dactolisib | MCF 10A | 10.0 | nM | 24 | hr | 252.70 | 145.39 | p-S6 | 245.07 | |
| Gefitinib | T47D | 10.0 | nM | 6 | hr | 190.29 | 104.62 | p-S6 | 457.27 | |
| Gefitinib | T47D | 10.0 | nM | 24 | hr | 168.20 | 122.54 | p-S6 | 349.17 | |
| Torkinib | T47D | 1.78 | nM | 6 | hr | 172.62 | 97.03 | p-S6 | 458.47 | |
| Torkinib | T47D | 1.78 | nM | 24 | hr | 169.91 | 110.68 | p-S6 | 342.79 | |
| GSK1059615 | T47D | 10.0 | nM | 6 | hr | 182.36 | 97.77 | p-S6 | 446.34 | |
| GSK1059615 | T47D | 10.0 | nM | 24 | hr | 158.27 | 106.60 | p-S6 | 343.84 | |
| MK2206 | T47D | 10.0 | nM | 6 | hr | 95.31 | 43.47 | p-S6 | 46.03 | |
| MK2206 | T47D | 10.0 | nM | 24 | hr | 156.66 | 102.74 | p-S6 | 357.79 | |
| Triciribine | T47D | 10.0 | nM | 6 | hr | 102.93 | 62.01 | p-S6 | 78.53 | |
| Triciribine | T47D | 10.0 | nM | 24 | hr | 158.54 | 107.03 | p-S6 | 374.63 | |