Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Gefitinib | AU565 | 10.0 | nM | 24 | hr | 578.95 | 132.32 | p-4EBP1 | 159.55 | |
| Torkinib | AU565 | 1.78 | nM | 6 | hr | 314.58 | 59.69 | p-4EBP1 | 74.62 | |
| Torkinib | AU565 | 1.78 | nM | 24 | hr | 444.44 | 115.02 | p-4EBP1 | 175.73 | |
| GSK1059615 | AU565 | 10.0 | nM | 6 | hr | 326.98 | 81.03 | p-4EBP1 | 97.82 | |
| GSK1059615 | AU565 | 10.0 | nM | 24 | hr | 419.93 | 125.00 | p-4EBP1 | 171.14 | |
| MK2206 | AU565 | 10.0 | nM | 6 | hr | 290.33 | 70.47 | p-4EBP1 | 87.48 | |
| MK2206 | AU565 | 10.0 | nM | 24 | hr | 388.98 | 123.91 | p-4EBP1 | 182.04 | |
| Triciribine | AU565 | 10.0 | nM | 6 | hr | 303.55 | 73.81 | p-4EBP1 | 96.67 | |
| Triciribine | AU565 | 10.0 | nM | 24 | hr | 483.38 | 131.11 | p-4EBP1 | 202.25 | |
| Dactolisib | AU565 | 10.0 | nM | 6 | hr | 265.79 | 60.68 | p-4EBP1 | 71.04 | |
| Dactolisib | AU565 | 10.0 | nM | 24 | hr | 490.21 | 100.31 | p-4EBP1 | 145.62 | |
| Gefitinib | HCC1954 | 10.0 | nM | 6 | hr | 245.75 | 64.95 | p-4EBP1 | 77.93 | |
| Gefitinib | HCC1954 | 10.0 | nM | 24 | hr | 287.38 | 129.52 | p-4EBP1 | 138.88 | |
| Torkinib | HCC1954 | 1.78 | nM | 6 | hr | 212.65 | 51.08 | p-4EBP1 | 63.09 | |
| Torkinib | HCC1954 | 1.78 | nM | 24 | hr | 284.82 | 122.84 | p-4EBP1 | 124.06 | |
| GSK1059615 | HCC1954 | 10.0 | nM | 6 | hr | 337.36 | 90.47 | p-4EBP1 | 107.28 | |
| GSK1059615 | HCC1954 | 10.0 | nM | 24 | hr | 289.47 | 125.09 | p-4EBP1 | 127.59 | |
| MK2206 | HCC1954 | 10.0 | nM | 6 | hr | 185.17 | 54.04 | p-4EBP1 | 77.68 | |
| MK2206 | HCC1954 | 10.0 | nM | 24 | hr | 282.44 | 126.20 | p-4EBP1 | 148.52 | |
| Triciribine | HCC1954 | 10.0 | nM | 6 | hr | 269.46 | 93.28 | p-4EBP1 | 122.37 | |
| Triciribine | HCC1954 | 10.0 | nM | 24 | hr | 300.41 | 117.49 | p-4EBP1 | 132.01 | |
| Dactolisib | HCC1954 | 10.0 | nM | 6 | hr | 225.45 | 79.13 | p-4EBP1 | 63.25 | |
| Dactolisib | HCC1954 | 10.0 | nM | 24 | hr | 286.89 | 98.96 | p-4EBP1 | 87.39 | |
| Gefitinib | MCF 10A | 10.0 | nM | 6 | hr | 392.32 | 167.11 | p-4EBP1 | 286.87 | |
| Gefitinib | MCF 10A | 10.0 | nM | 24 | hr | 269.57 | 156.39 | p-4EBP1 | 207.59 | |