HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Dactolisib	AU565	100.0	nM	6	hr	290.65	59.15	p-Akt	17.08
Dactolisib	AU565	100.0	nM	24	hr	377.63	60.16	p-Akt	25.52
Gefitinib	HCC1954	100.0	nM	6	hr	166.09	41.51	p-Akt	23.50
Gefitinib	HCC1954	100.0	nM	24	hr	271.49	112.65	p-Akt	74.36
Torkinib	HCC1954	31.6	nM	6	hr	150.07	28.76	p-Akt	14.38
Torkinib	HCC1954	31.6	nM	24	hr	250.65	86.99	p-Akt	39.42
GSK1059615	HCC1954	100.0	nM	6	hr	324.83	87.89	p-Akt	34.01
GSK1059615	HCC1954	100.0	nM	24	hr	285.12	84.64	p-Akt	37.56
MK2206	HCC1954	100.0	nM	6	hr	239.59	77.83	p-Akt	17.44
MK2206	HCC1954	100.0	nM	24	hr	248.97	102.29	p-Akt	31.95
Triciribine	HCC1954	100.0	nM	6	hr	200.10	73.80	p-Akt	29.38
Triciribine	HCC1954	100.0	nM	24	hr	238.17	94.17	p-Akt	36.41
Dactolisib	HCC1954	100.0	nM	6	hr	186.97	55.42	p-Akt	16.95
Dactolisib	HCC1954	100.0	nM	24	hr	240.30	68.59	p-Akt	21.56
Gefitinib	MCF 10A	100.0	nM	6	hr	345.12	168.30	p-Akt	37.38
Gefitinib	MCF 10A	100.0	nM	24	hr	258.63	122.31	p-Akt	28.67
Torkinib	MCF 10A	31.6	nM	6	hr	436.07	147.11	p-Akt	29.06
Torkinib	MCF 10A	31.6	nM	24	hr	400.54	150.17	p-Akt	24.66
GSK1059615	MCF 10A	100.0	nM	6	hr	316.39	158.33	p-Akt	27.50
GSK1059615	MCF 10A	100.0	nM	24	hr	326.44	133.59	p-Akt	27.72
MK2206	MCF 10A	100.0	nM	6	hr	358.46	151.32	p-Akt	25.55
MK2206	MCF 10A	100.0	nM	24	hr	301.03	149.65	p-Akt	23.12
Triciribine	MCF 10A	100.0	nM	6	hr	360.87	152.35	p-Akt	25.66
Triciribine	MCF 10A	100.0	nM	24	hr	231.53	128.71	p-Akt	20.57
Dactolisib	MCF 10A	100.0	nM	6	hr	342.01	143.79	p-Akt	24.33

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