HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Triciribine	MCF 10A	31.6	nM	24	hr	257.99	128.96	p-Akt	24.48
Dactolisib	MCF 10A	31.6	nM	6	hr	378.27	159.78	p-Akt	36.16
Dactolisib	MCF 10A	31.6	nM	24	hr	326.56	145.16	p-Akt	30.88
Gefitinib	T47D	31.6	nM	6	hr	167.03	97.05	p-Akt	101.76
Gefitinib	T47D	31.6	nM	24	hr	155.72	101.88	p-Akt	76.48
Torkinib	T47D	7.5	nM	6	hr	157.46	86.43	p-Akt	48.47
Torkinib	T47D	7.5	nM	24	hr	144.08	65.96	p-Akt	33.04
GSK1059615	T47D	31.6	nM	6	hr	168.17	85.32	p-Akt	73.10
GSK1059615	T47D	31.6	nM	24	hr	155.80	86.40	p-Akt	49.01
MK2206	T47D	31.6	nM	6	hr	105.79	49.19	p-Akt	9.27
MK2206	T47D	31.6	nM	24	hr	146.52	86.34	p-Akt	26.31
Triciribine	T47D	31.6	nM	6	hr	111.54	58.38	p-Akt	17.15
Triciribine	T47D	31.6	nM	24	hr	173.98	88.45	p-Akt	50.47
Dactolisib	T47D	31.6	nM	6	hr	88.70	45.24	p-Akt	10.08
Dactolisib	T47D	31.6	nM	24	hr	113.51	47.76	p-Akt	26.04
Gefitinib	AU565	100.0	nM	6	hr	221.28	52.62	p-Akt	23.51
Gefitinib	AU565	100.0	nM	24	hr	438.46	106.15	p-Akt	119.62
Torkinib	AU565	31.6	nM	6	hr	280.52	52.21	p-Akt	15.00
Torkinib	AU565	31.6	nM	24	hr	412.00	70.44	p-Akt	34.30
GSK1059615	AU565	100.0	nM	6	hr	223.60	51.25	p-Akt	23.72
GSK1059615	AU565	100.0	nM	24	hr	496.50	107.87	p-Akt	88.78
MK2206	AU565	100.0	nM	6	hr	217.60	53.69	p-Akt	13.47
MK2206	AU565	100.0	nM	24	hr	334.04	92.53	p-Akt	29.08
Triciribine	AU565	100.0	nM	6	hr	301.03	74.23	p-Akt	21.74
Triciribine	AU565	100.0	nM	24	hr	480.85	96.79	p-Akt	57.97

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