HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Dactolisib	MCF 10A	100.0	nM	24	hr	343.00	90.76	p-Akt	19.96
Gefitinib	T47D	100.0	nM	6	hr	165.65	99.07	p-Akt	102.82
Gefitinib	T47D	100.0	nM	24	hr	153.51	95.94	p-Akt	73.78
Torkinib	T47D	31.6	nM	6	hr	157.45	81.63	p-Akt	32.89
Torkinib	T47D	31.6	nM	24	hr	120.65	41.23	p-Akt	22.89
GSK1059615	T47D	100.0	nM	6	hr	158.85	79.78	p-Akt	56.09
GSK1059615	T47D	100.0	nM	24	hr	151.19	70.37	p-Akt	36.54
MK2206	T47D	100.0	nM	6	hr	95.92	42.78	p-Akt	7.64
MK2206	T47D	100.0	nM	24	hr	135.00	67.06	p-Akt	17.61
Triciribine	T47D	100.0	nM	6	hr	113.51	61.24	p-Akt	15.00
Triciribine	T47D	100.0	nM	24	hr	172.96	80.38	p-Akt	42.98
Dactolisib	T47D	100.0	nM	6	hr	101.93	53.36	p-Akt	8.50
Dactolisib	T47D	100.0	nM	24	hr	121.98	38.12	p-Akt	19.84
Gefitinib	AU565	316.0	nM	6	hr	234.01	54.85	p-Akt	22.11
Gefitinib	AU565	316.0	nM	24	hr	399.13	99.71	p-Akt	107.30
Torkinib	AU565	133.0	nM	6	hr	314.14	57.99	p-Akt	14.98
Torkinib	AU565	133.0	nM	24	hr	395.71	61.17	p-Akt	22.66
GSK1059615	AU565	316.0	nM	6	hr	232.75	48.96	p-Akt	23.52
GSK1059615	AU565	316.0	nM	24	hr	474.59	87.91	p-Akt	63.03
MK2206	AU565	316.0	nM	6	hr	266.67	61.68	p-Akt	13.97
MK2206	AU565	316.0	nM	24	hr	320.76	76.81	p-Akt	22.30
Triciribine	AU565	316.0	nM	6	hr	344.20	83.25	p-Akt	21.62
Triciribine	AU565	316.0	nM	24	hr	468.57	85.00	p-Akt	42.85
Dactolisib	AU565	316.0	nM	6	hr	300.22	59.06	p-Akt	16.85
Dactolisib	AU565	316.0	nM	24	hr	403.53	59.74	p-Akt	21.21

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