HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Dactolisib	MCF 10A	3.16	nM	6	hr	359.11	153.48	p-4EBP1	334.13
Dactolisib	MCF 10A	3.16	nM	24	hr	255.59	136.13	p-4EBP1	213.49
Gefitinib	T47D	3.16	nM	6	hr	187.41	98.66	p-4EBP1	463.23
Gefitinib	T47D	3.16	nM	24	hr	160.42	122.88	p-4EBP1	428.34
Torkinib	T47D	0.422	nM	6	hr	171.37	85.81	p-4EBP1	478.72
Torkinib	T47D	0.422	nM	24	hr	149.80	104.46	p-4EBP1	382.48
GSK1059615	T47D	3.16	nM	6	hr	163.11	84.87	p-4EBP1	470.43
GSK1059615	T47D	3.16	nM	24	hr	149.65	106.25	p-4EBP1	405.66
MK2206	T47D	3.16	nM	6	hr	93.38	33.38	p-4EBP1	75.21
MK2206	T47D	3.16	nM	24	hr	147.04	104.11	p-4EBP1	371.96
Triciribine	T47D	3.16	nM	6	hr	102.99	50.43	p-4EBP1	155.93
Triciribine	T47D	3.16	nM	24	hr	150.99	107.81	p-4EBP1	364.03
Dactolisib	T47D	3.16	nM	6	hr	90.48	33.02	p-4EBP1	89.29
Dactolisib	T47D	3.16	nM	24	hr	139.90	103.58	p-4EBP1	334.60
Gefitinib	AU565	10.0	nM	6	hr	266.21	59.03	p-4EBP1	67.26
Gefitinib	AU565	10.0	nM	24	hr	550.65	128.14	p-4EBP1	151.56
Torkinib	AU565	1.78	nM	6	hr	275.56	55.50	p-4EBP1	67.21
Torkinib	AU565	1.78	nM	24	hr	413.47	109.50	p-4EBP1	174.65
GSK1059615	AU565	10.0	nM	6	hr	256.55	65.09	p-4EBP1	78.23
GSK1059615	AU565	10.0	nM	24	hr	449.50	122.34	p-4EBP1	181.77
MK2206	AU565	10.0	nM	6	hr	340.94	77.61	p-4EBP1	117.81
MK2206	AU565	10.0	nM	24	hr	384.71	118.72	p-4EBP1	187.22
Triciribine	AU565	10.0	nM	6	hr	205.52	54.30	p-4EBP1	68.04
Triciribine	AU565	10.0	nM	24	hr	513.89	131.77	p-4EBP1	213.79
Dactolisib	AU565	10.0	nM	6	hr	237.61	52.79	p-4EBP1	59.93

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