HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
MK2206	HCC1954	31.6	nM	6	hr	241.19	75.59	p-Akt	18.23
MK2206	HCC1954	31.6	nM	24	hr	300.94	112.09	p-Akt	37.43
Triciribine	HCC1954	31.6	nM	6	hr	244.04	84.91	p-Akt	40.97
Triciribine	HCC1954	31.6	nM	24	hr	304.02	110.08	p-Akt	48.96
Dactolisib	HCC1954	31.6	nM	6	hr	184.53	45.81	p-Akt	19.34
Dactolisib	HCC1954	31.6	nM	24	hr	272.16	82.67	p-Akt	36.70
Gefitinib	MCF 10A	31.6	nM	6	hr	393.64	166.61	p-Akt	39.04
Gefitinib	MCF 10A	31.6	nM	24	hr	298.39	151.27	p-Akt	32.88
Torkinib	MCF 10A	7.5	nM	6	hr	476.93	164.79	p-Akt	37.69
Torkinib	MCF 10A	7.5	nM	24	hr	389.81	147.59	p-Akt	33.47
GSK1059615	MCF 10A	31.6	nM	6	hr	388.64	176.09	p-Akt	33.94
GSK1059615	MCF 10A	31.6	nM	24	hr	299.42	136.42	p-Akt	25.28
MK2206	MCF 10A	31.6	nM	6	hr	369.88	149.56	p-Akt	28.88
MK2206	MCF 10A	31.6	nM	24	hr	262.25	147.81	p-Akt	24.11
Triciribine	MCF 10A	31.6	nM	6	hr	372.05	150.92	p-Akt	29.10
Triciribine	MCF 10A	31.6	nM	24	hr	247.73	138.98	p-Akt	22.03
Dactolisib	MCF 10A	31.6	nM	6	hr	352.90	132.19	p-Akt	28.66
Dactolisib	MCF 10A	31.6	nM	24	hr	251.26	134.38	p-Akt	22.34
Gefitinib	T47D	31.6	nM	6	hr	170.27	94.43	p-Akt	100.21
Gefitinib	T47D	31.6	nM	24	hr	159.41	102.87	p-Akt	74.63
Torkinib	T47D	7.5	nM	6	hr	171.51	80.43	p-Akt	46.98
Torkinib	T47D	7.5	nM	24	hr	138.86	70.27	p-Akt	34.18
GSK1059615	T47D	31.6	nM	6	hr	170.36	83.95	p-Akt	77.52
GSK1059615	T47D	31.6	nM	24	hr	166.47	90.54	p-Akt	46.81
MK2206	T47D	31.6	nM	6	hr	95.85	34.35	p-Akt	8.13

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