HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
MK2206	T47D	31.6	nM	24	hr	148.65	79.91	p-Akt	25.94
Triciribine	T47D	31.6	nM	6	hr	99.99	51.97	p-Akt	15.00
Triciribine	T47D	31.6	nM	24	hr	170.55	95.55	p-Akt	51.77
Dactolisib	T47D	31.6	nM	6	hr	84.81	35.55	p-Akt	8.51
Dactolisib	T47D	31.6	nM	24	hr	115.24	48.85	p-Akt	25.43
Gefitinib	AU565	100.0	nM	6	hr	256.41	58.17	p-Akt	25.26
Gefitinib	AU565	100.0	nM	24	hr	487.81	111.78	p-Akt	128.85
Torkinib	AU565	31.6	nM	6	hr	308.58	54.18	p-Akt	15.29
Torkinib	AU565	31.6	nM	24	hr	411.83	71.19	p-Akt	32.74
GSK1059615	AU565	100.0	nM	6	hr	358.29	80.75	p-Akt	38.55
GSK1059615	AU565	100.0	nM	24	hr	503.48	100.73	p-Akt	73.85
MK2206	AU565	100.0	nM	6	hr	364.01	73.26	p-Akt	18.17
MK2206	AU565	100.0	nM	24	hr	383.72	87.26	p-Akt	30.79
Triciribine	AU565	100.0	nM	6	hr	255.98	65.84	p-Akt	18.08
Triciribine	AU565	100.0	nM	24	hr	552.62	106.48	p-Akt	64.22
Dactolisib	AU565	100.0	nM	6	hr	295.45	58.66	p-Akt	15.40
Dactolisib	AU565	100.0	nM	24	hr	469.99	63.40	p-Akt	26.02
Gefitinib	HCC1954	100.0	nM	6	hr	164.98	48.76	p-Akt	23.52
Gefitinib	HCC1954	100.0	nM	24	hr	275.32	116.64	p-Akt	73.65
Torkinib	HCC1954	31.6	nM	6	hr	162.33	28.59	p-Akt	14.31
Torkinib	HCC1954	31.6	nM	24	hr	263.14	91.22	p-Akt	39.45
GSK1059615	HCC1954	100.0	nM	6	hr	490.88	99.06	p-Akt	52.56
GSK1059615	HCC1954	100.0	nM	24	hr	293.77	91.79	p-Akt	37.28
MK2206	HCC1954	100.0	nM	6	hr	262.18	79.74	p-Akt	17.08
MK2206	HCC1954	100.0	nM	24	hr	290.05	108.17	p-Akt	25.98

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