Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| MK2206 | MCF 10A | 100.0 | nM | 6 | hr | 387.84 | 152.65 | p-4EBP1 | 359.27 | |
| MK2206 | MCF 10A | 100.0 | nM | 24 | hr | 267.60 | 168.79 | p-4EBP1 | 204.90 | |
| Triciribine | MCF 10A | 100.0 | nM | 6 | hr | 390.18 | 153.46 | p-4EBP1 | 360.59 | |
| Triciribine | MCF 10A | 100.0 | nM | 24 | hr | 233.97 | 155.96 | p-4EBP1 | 184.14 | |
| Dactolisib | MCF 10A | 100.0 | nM | 6 | hr | 352.97 | 128.10 | p-4EBP1 | 59.80 | |
| Dactolisib | MCF 10A | 100.0 | nM | 24 | hr | 315.69 | 93.24 | p-4EBP1 | 24.59 | |
| Gefitinib | T47D | 100.0 | nM | 6 | hr | 160.51 | 99.08 | p-4EBP1 | 483.73 | |
| Gefitinib | T47D | 100.0 | nM | 24 | hr | 143.88 | 111.89 | p-4EBP1 | 390.92 | |
| Torkinib | T47D | 31.6 | nM | 6 | hr | 152.82 | 76.33 | p-4EBP1 | 310.16 | |
| Torkinib | T47D | 31.6 | nM | 24 | hr | 124.43 | 49.09 | p-4EBP1 | 182.93 | |
| GSK1059615 | T47D | 100.0 | nM | 6 | hr | 161.08 | 79.36 | p-4EBP1 | 506.97 | |
| GSK1059615 | T47D | 100.0 | nM | 24 | hr | 146.73 | 75.48 | p-4EBP1 | 382.12 | |
| MK2206 | T47D | 100.0 | nM | 6 | hr | 93.04 | 34.39 | p-4EBP1 | 75.18 | |
| MK2206 | T47D | 100.0 | nM | 24 | hr | 137.94 | 84.66 | p-4EBP1 | 345.76 | |
| Triciribine | T47D | 100.0 | nM | 6 | hr | 104.28 | 51.90 | p-4EBP1 | 172.03 | |
| Triciribine | T47D | 100.0 | nM | 24 | hr | 154.96 | 92.67 | p-4EBP1 | 347.47 | |
| Dactolisib | T47D | 100.0 | nM | 6 | hr | 93.80 | 43.48 | p-4EBP1 | 61.08 | |
| Dactolisib | T47D | 100.0 | nM | 24 | hr | 105.99 | 39.21 | p-4EBP1 | 90.68 | |
| Gefitinib | AU565 | 316.0 | nM | 6 | hr | 214.01 | 52.78 | p-4EBP1 | 62.72 | |
| Gefitinib | AU565 | 316.0 | nM | 24 | hr | 414.76 | 95.73 | p-4EBP1 | 130.92 | |
| Torkinib | AU565 | 133.0 | nM | 6 | hr | 273.77 | 50.73 | p-4EBP1 | 12.35 | |
| Torkinib | AU565 | 133.0 | nM | 24 | hr | 366.54 | 67.97 | p-4EBP1 | 27.95 | |
| GSK1059615 | AU565 | 316.0 | nM | 6 | hr | 289.06 | 63.60 | p-4EBP1 | 86.03 | |
| GSK1059615 | AU565 | 316.0 | nM | 24 | hr | 482.72 | 91.32 | p-4EBP1 | 156.20 | |
| MK2206 | AU565 | 316.0 | nM | 6 | hr | 333.41 | 71.95 | p-4EBP1 | 113.09 | |