Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | T47D | 0 (control) | 6 | hr | 170.67 | 95.63 | p-S6 | 471.82 | | |
| GSK1059615 | T47D | 0 (control) | 24 | hr | 166.64 | 96.53 | p-S6 | 333.24 | | |
| MK2206 | T47D | 0 (control) | 6 | hr | 93.24 | 32.03 | p-S6 | 42.80 | | |
| MK2206 | T47D | 0 (control) | 24 | hr | 171.54 | 104.31 | p-S6 | 349.95 | | |
| Triciribine | T47D | 0 (control) | 6 | hr | 93.67 | 36.69 | p-S6 | 48.97 | | |
| Triciribine | T47D | 0 (control) | 24 | hr | 178.57 | 98.11 | p-S6 | 353.20 | | |
| Dactolisib | T47D | 0 (control) | 6 | hr | 102.85 | 43.35 | p-S6 | 72.78 | | |
| Dactolisib | T47D | 0 (control) | 24 | hr | 150.93 | 113.70 | p-S6 | 316.63 | | |
| Gefitinib | AU565 | 1.0 | nM | 6 | hr | 331.93 | 71.96 | p-S6 | 204.40 | |
| Gefitinib | AU565 | 1.0 | nM | 24 | hr | 634.91 | 132.12 | p-S6 | 494.50 | |
| Torkinib | AU565 | 0.1 | nM | 6 | hr | 259.18 | 62.54 | p-S6 | 155.57 | |
| Torkinib | AU565 | 0.1 | nM | 24 | hr | 500.67 | 124.40 | p-S6 | 484.77 | |
| GSK1059615 | AU565 | 1.0 | nM | 6 | hr | 364.61 | 89.05 | p-S6 | 229.90 | |
| GSK1059615 | AU565 | 1.0 | nM | 24 | hr | 458.33 | 123.46 | p-S6 | 585.14 | |
| MK2206 | AU565 | 1.0 | nM | 6 | hr | 254.16 | 70.09 | p-S6 | 156.06 | |
| MK2206 | AU565 | 1.0 | nM | 24 | hr | 399.01 | 123.18 | p-S6 | 489.38 | |
| Triciribine | AU565 | 1.0 | nM | 6 | hr | 235.86 | 67.93 | p-S6 | 136.84 | |
| Triciribine | AU565 | 1.0 | nM | 24 | hr | 515.85 | 125.87 | p-S6 | 463.78 | |
| Dactolisib | AU565 | 1.0 | nM | 6 | hr | 206.88 | 49.24 | p-S6 | 116.08 | |
| Dactolisib | AU565 | 1.0 | nM | 24 | hr | 525.60 | 117.07 | p-S6 | 425.59 | |
| Gefitinib | HCC1954 | 1.0 | nM | 6 | hr | 332.80 | 81.45 | p-S6 | 177.32 | |
| Gefitinib | HCC1954 | 1.0 | nM | 24 | hr | 309.63 | 117.63 | p-S6 | 288.76 | |
| Torkinib | HCC1954 | 0.1 | nM | 6 | hr | 184.48 | 44.56 | p-S6 | 110.17 | |
| Torkinib | HCC1954 | 0.1 | nM | 24 | hr | 274.70 | 113.00 | p-S6 | 380.78 | |
| GSK1059615 | HCC1954 | 1.0 | nM | 6 | hr | 407.93 | 94.25 | p-S6 | 351.69 | |