Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | HCC1954 | 3.16 | uM | 6 | hr | 300.92 | 70.53 | p-Akt | 15.68 | |
| GSK1059615 | HCC1954 | 3.16 | uM | 24 | hr | 295.96 | 56.00 | p-Akt | 18.33 | |
| MK2206 | HCC1954 | 3.16 | uM | 6 | hr | 220.00 | 47.07 | p-Akt | 18.05 | |
| MK2206 | HCC1954 | 3.16 | uM | 24 | hr | 267.95 | 73.72 | p-Akt | 18.89 | |
| Triciribine | HCC1954 | 3.16 | uM | 6 | hr | 197.34 | 60.02 | p-Akt | 22.58 | |
| Triciribine | HCC1954 | 3.16 | uM | 24 | hr | 233.49 | 88.09 | p-Akt | 26.48 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 270.38 | 74.22 | p-Akt | 17.89 | |
| Dactolisib | HCC1954 | 3.16 | uM | 24 | hr | 269.72 | 61.63 | p-Akt | 17.51 | |
| Gefitinib | MCF 10A | 3.16 | uM | 6 | hr | 178.52 | 137.75 | p-Akt | 27.81 | |
| Gefitinib | MCF 10A | 3.16 | uM | 24 | hr | 173.69 | 24.68 | p-Akt | 20.53 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 561.92 | 142.49 | p-Akt | 17.93 | |
| Torkinib | MCF 10A | 2.37 | uM | 24 | hr | 380.19 | 57.30 | p-Akt | 11.19 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 6 | hr | 193.57 | 116.39 | p-Akt | 14.46 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 24 | hr | 237.03 | 102.02 | p-Akt | 15.00 | |
| MK2206 | MCF 10A | 3.16 | uM | 6 | hr | 369.53 | 146.17 | p-Akt | 17.62 | |
| MK2206 | MCF 10A | 3.16 | uM | 24 | hr | 344.55 | 133.35 | p-Akt | 14.79 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 370.92 | 146.93 | p-Akt | 17.67 | |
| Triciribine | MCF 10A | 3.16 | uM | 24 | hr | 279.48 | 109.63 | p-Akt | 20.65 | |
| Dactolisib | MCF 10A | 3.16 | uM | 6 | hr | 289.93 | 138.14 | p-Akt | 17.26 | |
| Dactolisib | MCF 10A | 3.16 | uM | 24 | hr | 363.80 | 58.41 | p-Akt | 16.17 | |
| Gefitinib | T47D | 3.16 | uM | 6 | hr | 155.01 | 95.03 | p-Akt | 100.54 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 137.81 | 105.61 | p-Akt | 73.77 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 149.52 | 71.80 | p-Akt | 15.08 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 120.26 | 34.78 | p-Akt | 12.24 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 153.63 | 58.98 | p-Akt | 14.99 | |