Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Torkinib | T47D | 562.0 | nM | 24 | hr | 119.35 | 36.17 | p-Akt | 13.61 | |
| GSK1059615 | T47D | 1.0 | uM | 6 | hr | 158.41 | 63.89 | p-Akt | 21.30 | |
| GSK1059615 | T47D | 1.0 | uM | 24 | hr | 151.68 | 44.97 | p-Akt | 17.97 | |
| MK2206 | T47D | 1.0 | uM | 6 | hr | 107.58 | 49.92 | p-Akt | 7.19 | |
| MK2206 | T47D | 1.0 | uM | 24 | hr | 138.60 | 47.77 | p-Akt | 13.85 | |
| Triciribine | T47D | 1.0 | uM | 6 | hr | 119.47 | 61.20 | p-Akt | 13.24 | |
| Triciribine | T47D | 1.0 | uM | 24 | hr | 168.38 | 70.15 | p-Akt | 36.06 | |
| Dactolisib | T47D | 1.0 | uM | 6 | hr | 90.30 | 37.28 | p-Akt | 6.14 | |
| Dactolisib | T47D | 1.0 | uM | 24 | hr | 115.16 | 30.63 | p-Akt | 12.53 | |
| Gefitinib | AU565 | 3.16 | uM | 6 | hr | 207.63 | 45.48 | p-Akt | 16.31 | |
| Gefitinib | AU565 | 3.16 | uM | 24 | hr | 347.95 | 80.80 | p-Akt | 41.35 | |
| Torkinib | AU565 | 2.37 | uM | 6 | hr | 226.24 | 41.45 | p-Akt | 12.62 | |
| Torkinib | AU565 | 2.37 | uM | 24 | hr | 421.19 | 62.31 | p-Akt | 18.44 | |
| GSK1059615 | AU565 | 3.16 | uM | 6 | hr | 191.35 | 37.78 | p-Akt | 14.23 | |
| GSK1059615 | AU565 | 3.16 | uM | 24 | hr | 409.06 | 80.24 | p-Akt | 22.14 | |
| MK2206 | AU565 | 3.16 | uM | 6 | hr | 256.25 | 58.14 | p-Akt | 13.28 | |
| MK2206 | AU565 | 3.16 | uM | 24 | hr | 337.81 | 71.61 | p-Akt | 19.14 | |
| Triciribine | AU565 | 3.16 | uM | 6 | hr | 341.86 | 82.21 | p-Akt | 24.71 | |
| Triciribine | AU565 | 3.16 | uM | 24 | hr | 412.86 | 71.66 | p-Akt | 32.76 | |
| Dactolisib | AU565 | 3.16 | uM | 6 | hr | 317.65 | 70.54 | p-Akt | 17.86 | |
| Dactolisib | AU565 | 3.16 | uM | 24 | hr | 451.39 | 64.70 | p-Akt | 22.39 | |
| Gefitinib | HCC1954 | 3.16 | uM | 6 | hr | 128.34 | 30.50 | p-Akt | 19.47 | |
| Gefitinib | HCC1954 | 3.16 | uM | 24 | hr | 238.74 | 77.23 | p-Akt | 53.80 | |
| Torkinib | HCC1954 | 2.37 | uM | 6 | hr | 174.43 | 26.36 | p-Akt | 12.16 | |
| Torkinib | HCC1954 | 2.37 | uM | 24 | hr | 242.08 | 64.01 | p-Akt | 16.55 | |