Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK461364 | MDA-MB-175-VII | -4.4776 | 0.7103 | -4.6478 | -4.6477 | -4.9999 | 1.7670 | 0.0000 | 0.3335 | 7.1799 |
| PD173074 | SUM52PE | -4.4776 | 0.8683 | -7.4756 | -6.9774 | -7.7068 | 0.5208 | 0.2247 | 0.2454 | 5.3107 |
| PD173074 | 184A1 | -4.4776 | 0.8593 | -5.0370 | -4.8249 | -5.0956 | 1.9590 | 0.3079 | 0.3593 | 8.3583 |
| PD173074 | MCF12A | -4.4776 | 0.9229 | -4.6482 | -4.6481 | -4.6420 | 2.2590 | 0.0000 | 0.2917 | 8.0698 |
| Taxol | BT-474 | -4.4776 | 0.9747 | -7.8341 | -7.3713 | -7.9943 | 1.7390 | 0.3738 | 0.3738 | 5.7869 |
| PD173074 | T47DKBLUC | -4.4776 | 0.9441 | -4.9812 | -4.9812 | -5.0466 | 3.2220 | 0.0000 | 0.0233 | 7.4959 |
| PD173074 | 600MPE | -4.4776 | 0.9467 | -4.8978 | -4.8978 | -5.0321 | 3.2440 | 0.0000 | 0.0415 | 7.5061 |
| PD173074 | HCC2185 | -4.4776 | 0.7591 | -4.2904 | -4.4776 | -4.5540 | 2.3710 | 0.0000 | 0.7354 | 8.7965 |
| PD173074 | HCC3153 | -4.4776 | 0.9399 | -4.4281 | -4.4776 | -4.7664 | 1.4430 | 0.0000 | 0.5411 | 8.3169 |
| PD173074 | LY2 | -4.4776 | 0.9191 | -5.0191 | -4.9940 | -5.0821 | 3.9990 | 0.1032 | 0.1093 | 8.1745 |
| GSK461364 | ZR75B | -4.4776 | 0.8442 | -6.5221 | -5.0790 | -7.0316 | 2.1862 | 0.3160 | 0.4216 | 6.9822 |
| GSK1070916 | SUM185PE | -4.4776 | 0.9052 | -5.4942 | -5.4944 | -5.9594 | 1.3090 | 0.0000 | 0.0450 | 7.4398 |
| Taxol | HCC1428 | -4.4776 | 0.8373 | -7.8311 | -4.4776 | -6.0625 | 1.5830 | 0.7669 | 0.7669 | 8.2442 |
| Taxol | HCC1569 | -4.4776 | 0.9339 | -8.0131 | -4.4776 | -7.9203 | 3.9975 | 0.5523 | 0.5523 | 6.5838 |
| GSK461364 | MDA-MB-436 | -4.4776 | 0.8119 | -7.8636 | -7.3063 | -7.8969 | 2.3230 | 0.3729 | 0.3729 | 6.0263 |
| GSK1070916 | SUM159PT | -4.4776 | 0.9045 | -5.7426 | -5.7426 | -5.6673 | 0.5924 | 0.0000 | 0.1507 | 6.6500 |
| GSK461364 | MDA-MB-231 | -4.4776 | 0.8566 | -7.8021 | -7.7101 | -7.7688 | 3.9985 | 0.2728 | 0.2728 | 5.0535 |
| Taxol | HCC38 | -4.4776 | 0.9849 | -8.0341 | -7.9393 | -8.1832 | 1.9245 | 0.1710 | 0.1710 | 4.3121 |
| GSK461364 | HCC1428 | -4.4776 | 0.9592 | -4.9400 | -4.9399 | -5.2690 | 3.3400 | 0.0000 | 0.0203 | 7.7381 |
| GSK1070916 | SUM149PT | -4.4776 | 0.9459 | -5.4509 | -5.4508 | -5.5356 | 1.0515 | 0.0000 | 0.1207 | 6.9589 |
| GSK1070916 | AU565 | -4.4776 | 0.7600 | -5.2504 | -5.2504 | -5.5873 | 0.5535 | 0.0000 | 0.2719 | 6.7505 |
| Taxol | MDA-MB-175-VII | -4.4776 | 0.8420 | -7.9421 | -4.4776 | -7.7201 | 2.5515 | 0.7305 | 0.7305 | 7.5609 |
| GSK461364 | MDA-MB-453 | -4.4776 | 0.7675 | -8.1451 | -6.1011 | -8.1526 | 2.7515 | 0.4819 | 0.4819 | 6.1418 |
| PD173074 | 184B5 | -4.4776 | 0.8588 | -4.4590 | -4.4776 | -4.5299 | 3.9990 | 0.0000 | 0.5429 | 8.8444 |
| PD173074 | ZR-75-1 | -4.4776 | 0.8601 | -4.6280 | -4.6280 | -4.9060 | 1.5490 | 0.0000 | 0.3647 | 7.8117 |