Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Doxorubicin | HCC3153 | -6.2596 | 0.9648 | -6.5902 | -6.5902 | -6.9511 | 1.0970 | 0.0000 | 0.3026 | 7.7658 |
| Doxorubicin | SUM52PE | -6.2596 | 0.9158 | -6.3140 | -6.3140 | -6.6296 | 1.3770 | 0.0000 | 0.4570 | 8.0919 |
| Doxorubicin | SUM229PE | -6.2596 | 0.8997 | -6.5291 | -6.5291 | -6.6895 | 1.2090 | 0.0000 | 0.3208 | 7.7006 |
| Doxorubicin | UACC-893 | -6.2596 | 0.9220 | -6.7659 | -6.7659 | -7.2336 | 3.0060 | 0.0000 | 0.0296 | 7.4102 |
| Doxorubicin | T47D | -6.2596 | 0.8913 | -6.4580 | -6.4460 | -7.2470 | 0.8943 | 0.0146 | 0.3997 | 8.1427 |
| Doxorubicin | MCF7 | -6.2596 | 0.9750 | -6.7234 | -6.7235 | -6.9475 | 1.3200 | 0.0000 | 0.1963 | 7.9183 |
| Doxorubicin | SK-BR-3 | -6.2596 | 0.9787 | -6.9014 | -6.8981 | -7.1294 | 1.4280 | 0.0056 | 0.1131 | 7.3714 |
| Doxorubicin | AU565 | -6.2596 | 0.9064 | -7.2888 | -7.2496 | -7.4293 | 1.8740 | 0.0680 | 0.0814 | 7.0531 |
| Doxorubicin | BT-20 | -6.2596 | 0.9277 | -6.3089 | -6.3089 | -6.5270 | 2.3340 | 0.0000 | 0.4342 | 8.2808 |
| Doxorubicin | HCC1143 | -6.2596 | 0.9684 | -6.7690 | -6.7690 | -6.9395 | 1.4990 | 0.0000 | 0.1470 | 7.5211 |
| Doxorubicin | HCC1395 | -6.2596 | 0.8054 | -5.2156 | -6.2596 | -6.7053 | 0.4539 | 0.0000 | 0.7486 | 8.4055 |
| Doxorubicin | HCC1569 | -6.2596 | 0.8574 | -5.6508 | -6.2596 | -6.4796 | 0.4280 | 0.0000 | 0.6457 | 8.1424 |
| Doxorubicin | HCC1806 | -6.2596 | 0.9360 | -6.9901 | -6.9901 | -7.3056 | 1.2590 | 0.0000 | 0.1493 | 7.3923 |
| Doxorubicin | HCC38 | -6.2596 | 0.8958 | -7.5606 | -7.5605 | -8.1413 | 1.5120 | 0.0000 | 0.0107 | 6.2784 |
| Doxorubicin | HCC70 | -6.2596 | 0.8984 | -5.8822 | -6.2596 | -7.3316 | 0.7514 | 0.0000 | 0.6576 | 8.3593 |
| Docetaxel | HCC2185 | -5.0000 | 0.8601 | -8.4610 | -5.0000 | -8.5299 | 2.8345 | 0.6559 | 0.6559 | 7.0951 |
| Docetaxel | 600MPE | -5.0000 | 0.7992 | -7.6820 | -5.0000 | -7.1151 | 2.4180 | 0.7415 | 0.7415 | 8.2414 |
| Docetaxel | HCC3153 | -5.0000 | 0.9655 | -7.8850 | -7.4961 | -8.0029 | 1.5310 | 0.4040 | 0.4040 | 6.2205 |
| Docetaxel | MCF12A | -5.0000 | 0.9298 | -8.6260 | -8.2368 | -8.6178 | 1.3250 | 0.3435 | 0.3436 | 5.1394 |
| Docetaxel | 184A1 | -5.0000 | 0.7750 | -8.2270 | -5.0000 | -6.0351 | 1.3100 | 0.7160 | 0.7160 | 7.8073 |
| Docetaxel | T47DKBLUC | -5.0000 | 0.9620 | -7.7980 | -7.3631 | -7.9166 | 1.9650 | 0.4303 | 0.4303 | 6.4961 |
| Docetaxel | LY2 | -5.0000 | 0.9638 | -8.2275 | -7.2971 | -8.2340 | 1.5105 | 0.3819 | 0.3819 | 5.9691 |
| Docetaxel | SUM185PE | -5.0000 | 0.9052 | -7.7910 | -5.0000 | -7.7962 | 3.9920 | 0.5991 | 0.5991 | 7.6798 |
| Docetaxel | SUM159PT | -5.0000 | 0.9753 | -8.7915 | -8.7477 | -8.8094 | 2.1380 | 0.0956 | 0.0956 | 3.6627 |
| Docetaxel | SUM229PE | -5.0000 | 0.9860 | -7.9790 | -7.6742 | -7.9582 | 1.6750 | 0.3458 | 0.3458 | 5.9634 |